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Anorexia and urinary zinc excretion after administration of L-histidine in humans


, : Anorexia and urinary zinc excretion after administration of L-histidine in humans. American journal of clinical nutrition 33(3): 540

L-histidine is effective in producing anorexia and alteration of zinc metabolism. Urinary excretion of zinc increases two or threefold when anorexia is observed. Large doses of histidine, however, are needed to produce and maintain increased levels of urinary zinc excretion in order for anorexia to persist. Since doses as high as 9-12 g daily may be required to produce anorexia, screening for harmful side effects of rapid depletion of body zinc will be necessary.

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PMID: 6928339


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