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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

, : Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307(5706): 58-62

Solid tumors require blood vessels for growth, and many new cancer therapies are directed against the tumor vasculature. The widely held view is that these antiangiogenic therapies should destroy the tumor vasculature, thereby depriving the tumor of oxygen and nutrients. Here, I review emerging evidence supporting an alternative hypothesis--that certain antiangiogenic agents can also transiently "normalize" the abnormal structure and function of tumor vasculature to make it more efficient for oxygen and drug delivery. Drugs that induce vascular normalization can alleviate hypoxia and increase the efficacy of conventional therapies if both are carefully scheduled. A better understanding of the molecular and cellular underpinnings of vascular normalization may ultimately lead to more effective therapies not only for cancer but also for diseases with abnormal vasculature, as well as regenerative medicine, in which the goal is to create and maintain a functionally normal vasculature.


PMID: 15637262

DOI: 10.1126/science.1104819

Other references

Celik, G.; Karabiykoglu, G., 1998: Local and peripheral plasma endothelin-1 in pulmonary hypertension secondary to chronic obstructive pulmonary diseases. Endothelin-1 (ET-1) has been described to have crucial effects in the initiation and evolution of pulmonary hypertension (PH) secondary to cardiac disorders. However, the precise role of ET-1 in PH induced by chronic obstructive pulmonary disease...

Kozuo, G.; Averdukh, B., 1979: Moldavian sherry and methods of improving its quality. Novoe v vinodelii Moldavii Agrarno promyshlennoe ob"edinenie Moldavskoi SSR po vinogradarstvu i vinodeliiu "Moldvinprom" i Nauchno proizvodstvennoe agropromyshlennoe ob"edinenie "IAloveny" redaktsionnaia kollegiia: R P Khachaturian otv redaktori dr: 8

Habibullah, V.M.; Ragunathan, V., 1976: Relative sensitivity of wild and mutant isolates of Fusarium oxysporum f. melonis to benlate. Results, presented at a symposium on plant protection at Tamil Nadu Agric. Univ. in Feb. 1976, showed that wild and mutant isolates differed in sensitivity to different benlate concs. The X-ray mutants developed tolerance, suggesting that benlate...

Jordan, D.S., 1923: On the family of Achiridae or Broad-Soles, with description of a new species Achirus barnharti from California. University of California Publications in Zoology, 26: 1-14

Hemmendinger, S.; Beretz, A.; Lanza, F.; Cazenave, J.P., 1986: Methods of studying platelet function. Biological markers of the activation of human platelets in vivo and in vitro. Platelets play a key role in hemostasis, thrombosis, atherosclerosis and their pathological consequences. It is possible to follow platelet activation in vivo by measuring bleeding time, platelet count, existence of circulating platelet aggregates...

Brouwer, B.; Ziolkowska, A.; Bagard, M.; Keech, O.; Gardeström, P., 2012: The impact of light intensity on shade-induced leaf senescence. Plants often have to cope with altered light conditions, which in leaves induces various physiological responses ranging from photosynthetic acclimation to leaf senescence. However, our knowledge of the regulatory pathways by which shade and darkn...

Ohara, N.; Kaneko, M.; Nishibori, T.; Sato, K.; Furukawa, T.; Koike, T.; Sone, H.; Kaneko, K.; Kamoi, K., 2016: Fulminant Type 1 Diabetes Mellitus Associated with Coxsackie Virus Type A2 Infection: A Case Report and Literature Review. A 65-year-old Japanese man presented to our hospital in June 2013 with a 6-day history of fever and fatigue, a 24-h history of thirst, and polyuria. His temperature was 37.8°C and he was alert. However, laboratory tests revealed severe hyperglyce...

Abraham G.E., 1972: Radio immunoassay of testosterone in murine plasma. Analytical Letters: 773-783

Nikiforov, L.I.; Jilavyan, K.A.; Zharkov, I.I.; Zharikov, V.P.; Filippov, V.V.; Sarkisov, K.A.; Tsvetkov, E.I.; Maslovskii, K.A.; Makarchenko, V.A., 1976: Storage life of production batches of LTF-130 ringworm vaccine. Trials involving 267 calves showed that the freeze-dried vaccine retained full immunogenicity for at least 13 months.

Porceddu, S.V., 2015: Insights into the relationship between HPV/p16 status, hypoxia imaging and treatment outcomes in head and neck cancer. Journal of Medical Imaging and Radiation Oncology 58(1): 98-100