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Plasma insulin in response to enterostatin and effect of adrenalectomy in rats


, : Plasma insulin in response to enterostatin and effect of adrenalectomy in rats. Obesity Research 4(6): 513-519

Enterostatin has previously been reported to alter serum insulin and corticosterone levels after central administration of the peptide. The purpose of the present study was to investigate the effect of peripheral administration of enterostatin on insulin and corticosterone levels as well as the response of plasma insulin to enterostatin administration in adrenalectomized rats. Female Sprague-Dawley rats were given a bolus injection intravenously with enterostatin alone or together with glucose. Enterostatin increased basal plasma levels of insulin, but significantly inhibited the increase in plasma insulin stimulated by glucose. Plasma corticosterone levels were not altered after a single intravenous injection of enterostatin. In rats infused chronically with enterostatin, plasma insulin levels were significantly reduced and plasma corticosterone levels were increased. The daily food intake was lower in these rats, but there was no effect on body weight. After adrenalectomy, the responsiveness of plasma insulin to enterostatin infusion was completely abolished. Furthermore, adrenalectomy itself reduced basal plasma levels of insulin and increased plasma levels of endogenous enterostatin. These results suggest that peripheral enterostatin administration produces a similar effect as central infusion of the peptide, and that the glucocorticoid hormones are involved in the regulation of plasma insulin by enterostatin.

US$19.90

PMID: 8946436

DOI: 10.1002/j.1550-8528.1996.tb00265.x


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Bianconi, A.; Natali, F.; Alosi, M.L.; Grande, S.; Lanzara, A.; Saini, N.L.; Brunelli, M., 2004: TDXAS study of the conformational landscape of MbCO. Journal of Synchrotron Radiation 6(Pt 3): 389-391

Einbrodt, H.J.; Schiereck, F.W.; Kinny, H., 1973: Lead in calcareous deposits of the human placenta. Archiv für Gynakologie 213(3): 303-306

Serganov, A., 2009: The long and the short of riboswitches. Regulatory mRNA elements or riboswitches specifically control the expression of a large number of genes in response to various cellular metabolites. The basis for selectivity of regulation is programmed in the evolutionarily conserved metabolite-s...

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Roy, D.Nath., 1902: Two Cases of Death from Suffocation. Indian Medical Gazette 37(11): 454-454

Newland, J.A., 2005: NPs called to duty in Katrina aftermath. Nurse Practitioner 30(10): 11-11

Roze, Janis A., 1994: Notes on taxonomy of venomous coral snakes (Elapidae) of South America. Bulletin of the Maryland Herpetological Society. December; 304: 177-185

Rellstab, C.; Maurer, V.; Zeh, M.; Buergi, H.-Rudolf; Spaak, P., 2007: Temporary collapse of the Daphnia population in turbid and ultra-oligotrophic Lake Brienz. The cyclical parthenogen Daphnia is a key species in aquatic food webs. Its abundance is influenced by environmental factors like food quantity and quality, predation, diseases, temperature and washout by discharge. In ultra-oligotrophic Lake Bri...

Keating, M.A.; Rink, R.C.; Bauer, S.B.; Krarup, C.; Dyro, F.M.; Winston, K.R.; Shillito, J.; Fischer, E.G.; Retik, A.B., 1988: Neurourological implications of the changing approach in management of occult spinal lesions. Occult lesions of the spine in children are a rare but recognizable cause of neurogenic dysfunction involving the lower extremities, and lower urinary and gastrointestinal tracts. We report the preoperative and postoperative urodynamic findings in...

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