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Rapid and efficient isolation of the nicotinic receptor antagonist methyllycaconitine from Delphinium: assignment of the methylsuccinimide absolute stereochemistry as S

, : Rapid and efficient isolation of the nicotinic receptor antagonist methyllycaconitine from Delphinium: assignment of the methylsuccinimide absolute stereochemistry as S. Tetrahedron letters: the international organ for the rapid ication of preliminary communications in organic chemistry, 35(46): 8701-8704

Methyllycaconitine (MLA) has been isolated from Garden Hybrid Delphinium and purified by vacuum liquid chromatography 13C NMR and optical rotation have been used to characterize the absolute configuration of the methylsuccinimide moiety as S. Ligand binding assays confirmed the potency of MLA and its selectivity for alpha-bungarotoxin-sensitive neuronal nicotinic acetylcholine receptors.


DOI: 10.1016/s0040-4039(00)78476-0

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