geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy


, : Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 109(6): 2303-2309

Although imatinib induces marked responses in patients with chronic myeloid leukemia (CML), resistance is increasingly problematic, and treatment options for imatinib-resistant or -intolerant CML are limited. Dasatinib, a novel, highly potent, oral, multitargeted kinase inhibitor of BCR-ABL and SRC family kinases, induced cytogenetic responses in a phase 1 study in imatinib-resistant or -intolerant CML and was well tolerated. Initial results are presented from a phase 2 study of 186 patients with imatinib-resistant or -intolerant chronic-phase CML (CML-CP) designed to further establish the efficacy and safety of dasatinib (70 mg twice daily). At 8-months' follow-up, dasatinib induced notable responses, with 90% and 52% of patients achieving complete hematologic and major cytogenetic responses (MCyR), respectively. Responses were long lasting: only 2% of patients achieving MCyR progressed or died. Importantly, comparable responses were achieved by patients carrying BCR-ABL mutations conferring imatinib resistance. Dasatinib also induced molecular responses, reducing BCR-ABL/ABL transcript ratios from 66% at baseline to 2.6% at 9 months. Nonhematologic adverse events were generally mild to moderate, and most cytopenias were effectively managed with dose modifications. Cross-intolerance with imatinib was not evident. To conclude, dasatinib induces notable responses in imatinib-resistant or -intolerant CML-CP, is well tolerated, and represents a promising therapeutic option for these patients. This trial was registered at www.clinicaltrials.gov as CA180013.

US$29.90


Other references

Hertzanu, Y.; Bar-Ziv, J., 1990: Case report 606: Gas-filled subchondral cyst of ilium secondary to osteoarthritis of the sacroiliac joint. Skeletal Radiology 19(3): 225-226

Aumaitre, A.; Morvan, C.; Quere, J.P.; Peiniau, J.; Vallet, G., 1982: Potential litter size and winter breeding in free-living wild sows (Sus scrofa scrofa). The genital tracts of 697 sows from a closed forest, slaughtered between 1974 and 1981, and 288 from an open forest, slaughtered between 1977 and 1981, were examined. 396 and 110 of the sows from the 2 forests resp. were pregnant. The data obtaine...

Surowiak, Z.; Brodacki, J.; Zajosz, H., 1978: Electronic system for investigation of the electrical hysteresis of ferroelectric thin films with high dielectric losses. A description is given of operating principles and technical data of an electronic system to investigate an electric hysteresis phenomenon of ferroelectric thin films with high dielectric losses. Two hysteresis loops, the compensated and the nonco...

Guillot, J.G.; Lefebvre, M.; Weber, J.P., 1997: Determination of heroin, 6-acetylmorphine, and morphine in biological fluids using their propionyl derivatives with ion trap GC-MS. We present an analytical method for the determination of heroin, free 6-acetylmorphine (6-AM), and free morphine in blood, urine, and vitreous humor. This method is used in postmortem cases where heroin is the suspected cause of death. The analyti...

Piltti, K.M.; Haus, D.L.; Do, E.; Perez, H.; Anderson, A.J.; Cummings, B.J., 2012: Computer-aided 2D and 3D quantification of human stem cell fate from in vitro samples using Volocity high performance image analysis software. Accurate automated cell fate analysis of immunostained human stem cells from 2- and 3-dimensional (2D-3D) images would improve efficiency in field of stem cell research. Development of an accurate and precise tool that reduces variability and the...

Mathew, S.; Lund, R.J.; Strebeck, F.; Tustison, K.S.; Geurs, T.; Hruska, K.A., 2006: Reversal of the adynamic bone disorder and decreased vascular calcification in chronic kidney disease by sevelamer carbonate therapy. A model of chronic kidney disease (CKD)-induced vascular calcification (VC) that complicates the metabolic syndrome was produced. In this model, the metabolic syndrome is characterized by severe atherosclerotic plaque formation, hypertension, typ...

Snellen, H.A., 1950: Drainage of the pulmonary veins into the right auricle by way of a persistent left vena cava. Nederlands Tijdschrift Voor Geneeskunde 94(35): 2582-2583

Stewart, T.J.; Fernando, G.J.P.; Frazer, I.H.; Leggatt, G.R., 2004: Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation. Immunotherapy of tumours using T cells expanded in vitro has met with mixed clinical success suggesting that a greater understanding of tumour/T-cell interaction is required. We used a HPV16E7 oncoprotein-based mouse tumour model to study this fur...

Baserga, A., 1971: Homeocytostasis. Prensa Medica Argentina 58(6): 326-328

Orłowski, Rł.; Tasior, M.; Staszewska-Krajewska, O.; Dobrzycki, Łukasz.; Schilf, W.; Ventura, B.; Cyrański, Mł.K.; Gryko, D.T., 2017: Hydrogen Bonds Involving Cavity NH Protons Drives Supramolecular Oligomerization of Amido-Corroles. trans-A<sub>2</sub> B-Corroles with amide substituents at different positions versus the macrocyclic core have been synthesized. Their self-organizing properties have been comprehensively evaluated both in solid-state and in solution....