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Effect of neurotrophin-3 on reinnervation of the larynx using the phrenic nerve transfer technique

, : Effect of neurotrophin-3 on reinnervation of the larynx using the phrenic nerve transfer technique. European Journal of Neuroscience 25(2): 331-340

Current techniques for reinnervation of the larynx following recurrent laryngeal nerve (RLN) injury are limited by synkinesis, which prevents functional recovery. Treatment with neurotrophins (NT) may enhance nerve regeneration and encourage more accurate reinnervation. This study presents the results of using the phrenic nerve transfer method, combined with NT-3 treatment, to selectively reinnervate the posterior cricoarytenoid (PCA) abductor muscle in a pig nerve injury model. RLN transection altered the phenotype and morphology of laryngeal muscles. In both the PCA and thyroarytenoid (TA) adductor muscle, fast type myosin heavy chain (MyHC) protein was decreased while slow type MyHC was increased. These changes were accompanied with a significant reduction in muscle fibre diameter. Following nerve repair there was a progressive normalization of MyHC phenotype and increased muscle fibre diameter in the PCA but not the TA muscle. This correlated with enhanced abductor function indicating the phrenic nerve accurately reinnervated the PCA muscle. Treatment with NT-3 significantly enhanced phrenic nerve regeneration but led to only a small increase in the number of reinnervated PCA muscle fibres and minimal effect on abductor muscle phenotype and morphology. Therefore, work exploring other growth factors, either alone or in combination with NT-3, is required.


PMID: 17284173

DOI: 10.1111/j.1460-9568.2007.05310.x

Other references

Fahmy, N.R.; Carr, D.B., 1993: Changes in beta endorphin levels during deliberate hypotension, their correlation with hemodynamics, catecholamines, and renin-angiotensin-aldosterone system. Anesthesiology (Hagerstown) 79(3A): A84

Terra, Fá; Marziale, M.Helena.Palucci.; Robazzi, M.Lú, 2014: Evaluation of self-esteem in nursing teachers at public and private universities. The aim of this study was to evaluate the self-esteem of Nursing faculty in public and private universities and compare the measures presented by two groups of teachers. This descriptive, correlational, cross-sectional quantitative study was condu...

Therios,I., 2008: Stress-induced accumulation of proline and mannitol. Proline is one of the most common compatible solutes accumulated in plants under stress conditions. It contributes to osmotic adjustment, preserves enzymes and other important cellular structures and is a reserve for carbon and nitrogen following...

Eder, J.; Kutacek, M.; Kefeli, V.; Vackova, K.; Langer, I., 1978: Comparison of in vivo activity of l tryptophan synthase ec in plants with a low and a high content of l tryptophan. The activity of L-tryptophan synthase (TS, EC was compared in vivo in seedlings of plants high in L-tryptophan (L-trp) (pea and kohlrabi) and low in this amino acid (maize). In maize the TS was studied both in the normal and in the opaqu...

Newton J.R.Jr; Grillo H.C.; Mathisen D.J., 1991: Main bronchial sleeve resection with pulmonary conservation. Twenty-seven main bronchial resections (19 left, 8 right) were performed without pulmonary resection between 1975 and 1991. The patients were 17 men and 9 women with an average age of 35 years (range, 20 to 65 years). Tumors comprised 55% of the l...

Cooper G.A.; Grant R.E., 1971: Lift high the lamp-shell, that its light may illuminate the principles and practices of correlation in the Permian. Bulletin of Canadian Petroleum Geology 19(2): 322-323

Bassi, A.; Vivaldi, E.A.; Ocampo-Garcés, Aán., 2009: The time course of the probability of transition into and out of REM sleep. A model of rapid eye movement (REM) sleep expression is proposed that assumes underlying regulatory mechanisms operating as inhomogenous Poisson processes, the overt results of which are the transitions into and out of REM sleep. Based on spontane...

Aytasheva, Z., G.; Bogdanova, E., D.; Kalimagambetov, A., M.; Chekalin, S., V.; Polimbetova, F., A., 2006: Isolation of trichomes from wheat and other species of flowering plants. Plant hairiness or pubescence as a specific phenotypical feature related to dehydration tolerance and resistance to leaf vermin is considered in this paper. A method for the isolation of trichomes, earlier developed for Arabidopsis Heynh., was fou...

Anonymous, 1996: Methylphenidate studies give "weak signal' of carcinogenic potential. American Journal of Health-System Pharmacy 53(6): 610-610

Pozos, T.C.; Sekler, I.; Cyert, M.S., 1996: The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers. Calcineurin, or PP2B, plays a critical role in mediating Ca-2+-dependent signaling in many cell types. In yeast cells, this highly conserved protein phosphatase regulates aspects of ion homeostasis and cell wall synthesis. We show that calcineurin...