+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of the melanocortin-3 receptor C17A and G241A variants on weight loss in childhood obesity

, : Effect of the melanocortin-3 receptor C17A and G241A variants on weight loss in childhood obesity. American Journal of Clinical Nutrition 85(4): 950-953

BACKGROUND:The central melanocortin system is critical for the long-term regulation of energy homeostasis. Melanocortin-3 receptor (MC3R) knock-out mice, despite being hypophagic, have increased fat mass and higher feed efficiency than do their wild-type littermates. OBJECTIVE:The aim was to evaluate whether, in childhood obesity, MC3R variants are associated with changes in fatness reduction as a consequence of a weight-reduction program. DESIGN:Molecular screening of the MC3R coding region in 184 obese children, 77 girls and 107 boys [x (plSEM) body mass index (BMI; in kg/mpo) z score: 3.3 pl 2.3; age 9.2 pl 2 y], was performed. BMI was evaluated at baseline and after 6 and 12 mo of the weight loss program. RESULTS:No new mutations were found. Two previously described polymorphisms, C17A (Thr6Lys) and G241A (Val81Ile), were observed in 20 patients in almost complete linkage disequilibrium. No significant differences in BMI z scores were observed at baseline of the weight-loss program between the genotypes; however, at follow-up, heterozygotes showed a significantly higher BMI z score (P = 0.03). When the patients were divided according to the amount of weight lost, a higher prevalence of heterozygotes was observed among subjects who lowered their BMI z score <1.5 (P = 0.03). CONCLUSION:These results suggest a gene-diet interaction between the MC3R C17A and G241A variants and a weight loss program for the ability to lose weight in childhood obesity.


PMID: 17413091

Other references

Steinfartz, S.; Hwang, U.W.ok; Tautz, D.; Oz, M.; Veith, M., 2002: Molecular phylogeny of the salamandrid genus Neurergus: Evidence for an intrageneric switch of reproductive biology. A molecular phylogeny of the salamandrid genus Neurergus was reconstructed based on two sections of the 12S and 16S mitochondrial ribosomal genes (810 bp), 19 allozyme and three plasma protein loci. When representative species of all closely relat...

D.R.nzo, F.; Broccia, M.Luisa.; Giavini, E.; Menegola, E., 2007: Relationship between embryonic histonic hyperacetylation and axial skeletal defects in mouse exposed to the three HDAC inhibitors apicidin, MS-275, and sodium butyrate. Some histone deacetylase inhibitors (HDACi) have recently been related to teratogenic effects in rodents. Skeletal defects have been directly associated with embryonic hyperacetylation of somitic nuclei after valproic acid or trichostatin A expos...

Salvacci, M.; Crafts-Brandner, S., 1995: Purification and properties of a unique nucleotide pyrophosphatase. Several unique proteins accumulate in soybean (Glycine max) leaves when the developing fruits are removed. In the present study, elevated levels of nucleotide pyrophosphatase and phosphodiesterase I activities were present in leaves of defruited s...

Sabeur, G.; Wantyghem, J.; Schuller, E., 1986: Stimulation of 2',3'-cyclic nucleotide 3'-phosphodiesterase in human lymphocytes by Robinia pseudoacacia lectin. 2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNP) activity was studied in human peripheral blood lymphocytes. Incubation of human lymphocytes with optimum mitogenic concentrations of Robinia pseudoacacia lectin produced an increase...

Rainsford, K.D., 1985: Preliminary investigations on the pharmacological control of catabolin-induced cartilage destruction in vitro. Agents and Actions 16(1-2): 55-57

Qiang Li; Jinming Yan, 2012: Assessing the health of agricultural land with emergy analysis and fuzzy logic in the major grain-producing region. Agricultural land is a complex system that combines natural ecology and social economy, and the health of agricultural land directly influences regional economic development and national food security. Emergy analysis is an effective method for va...

Fang Dajun; Chen Hanlin; Wang Pengyan; Tan Xiaodong, 1997: Paleomagnetic study and its tectonic significance for Tarim Basin in the Mesozoic. Diqiu Wulixue Bao = Acta Geophysica Sinica 40(1): 47-55

Saleiro, D.; Platanias, L.C., 2016: ULK1 in type I interferon response. Oncotarget 6(28): 24586-7

Roca Luis; Neda Justo, 1985: Evaluation of elastoplastic behavior in unconsolidated sand from the Faja Petrolifera of Orinoco. Memoria - Congreso Geologico Venezolano 6: 6194-6228

Fishbein, L., 1979: Potential halogenated industrial carcinogenic and mutagenic chemicals. I. Halogenated unsaturated hydrocarbons. This review of the use of halogenated saturated hydrocarbons in industry discusses the subsequent contamination of drinking water, dairy produce, meat, oils and fats, beverages, fruit and vegetables and bread with these substances.