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HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers


, : HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 144b(3): 291-299

The serotonin 2C (HTR2C) and 1A (HTR1A) receptors have been involved in suicide-related behaviors. We studied gene variants of both receptors in suicide attempters and completers. The sample was composed of 167 German suicide attempters (affective spectrum n = 107, schizophrenia spectrum n = 35, borderline personality disorder n = 25), 92 Caucasian individuals who committed suicide, 312 German healthy subjects, 152 Italian suicide attempters (major depression n = 68 and bipolar disorder n = 84), and 131 Italian healthy volunteers. HTR2C (SNP: rs547536, rs2192372, rs6318, rs2428707, rs4272555, rs1801412) and HTR1A (SNP: rs1423691, rs878567, and rs6295) variants were analyzed in the German sample. HTR2C rs6318 and HTR1A rs6295 were analyzed in the Italian sample. Haplotype analysis in relation to suicidal behaviors did not reveal any significant association. Single markers and haplotypes were not or only marginally associated with other related features, such as violence of suicide attempt, family history for suicide attempt or State-Trait Anger Expression Inventory (STAXI) and Questionnaire for Measuring Factors of Aggression (FAF) scores. In conclusion, our study does not support the notion that HTR2C and HTR1A gene variants are major contributors to suicide-, anger-, or aggression-related behaviors in our sample. (c) 2006 Wiley-Liss, Inc.

US$19.90

PMID: 17192951

DOI: 10.1002/ajmg.b.30432


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Ren, H-Ming.; Guo, Y.; Huang, S-Yun.; Zhang, K.; Yuen, M.M.F.; Fu, X-Zhu.; Yu, S.; Sun, R.; Wong, C-Ping., 2015: One-Step Preparation of Silver Hexagonal Microsheets as Electrically Conductive Adhesive Fillers for Printed Electronics. A facile one-step solution-phase chemical reduction method has been developed to synthesize Ag microsheets at room temperature. The morphology of Ag sheets is a regular hexagon more than 1 μm in size and about 200 nm in thickness. The hexagonal A...

Gerard, R.D.; Chan, L., 1996: Adenovirus-mediated gene transfer: strategies and applications in lipoprotein research. Adenovirus-mediated gene transfer into mammalian liver is a highly efficient process that can result in transduction frequencies approaching 100%. Coupled with efficient expression levels from these vectors, the transfer of genes encoding a variet...

Schendel, F.J.; Flickinger, M.C., 1992: Cloning and nucleotide sequence of the gene coding for aspartokinase II from a thermophilic methylotrophic Bacillus sp. The structural gene coding for the lysine-sensitive aspartokinase II of the methylotrophic thermotolerant Bacillus sp. strain MGA3 was cloned from a genomic library by complementation of an Escherichia coli auxotrophic mutant lacking all three asp...

Stegmayr, B.; Vinogradova, T.; Malyutina, S.; Peltonen, M.; Nikitin, Y.; Asplund, K., 2000: Widening gap of stroke between east and west: Eight-year trends in occurrence and risk factors in Russia and Sweden. Background and Purpose: Stroke is declining in most of the western and northern European countries, whereas no such decline is seen in eastern Europe. The aim of this study was to investigate trends in stroke attack rates and 28-day case fatality...

Stanghellini, V.; Camilleri, M.; Malagelada, J.R., 1987: Chronic idiopathic intestinal pseudo-obstruction: clinical and intestinal manometric findings. We report the clinical and intestinal manometric findings in a group of 42 patients with chronic idiopathic intestinal pseudo-obstruction evaluated at the Mayo Clinic. The main clinical manifestations in these patients were nausea and vomiting (83...

Brueske, C.H.; Applegate, H.G., 1966: The roles of adenosine triphosphate and glutathione in the inhibition of cyclosis by p-chlorobenzoic acid in Elodea densa. Adenosine tri-phosphate (ATP) applied alone accelerated cyclosis in Elodea densa. When applied simultaneously with p-chlorobenzoic acid (pCIBA), ATP nullified the inhibition of cyclosis by pCIBA. However, when ATP was applied prior to pCIBA, it on...

Zieliska, J., 1959: The lichens of the Debina reservation by Warsaw. The dominant association is Querceto-Carpinetum. Epiphytic spp. are most abundant in the lichen flora, which grows chiefly on oaks and hornbeams. They can also be found on single trees - lindens, pines, alders, aspens, elms and ashes. A characteri...

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