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Prenatal and perinatal risk factors for autism: a review and integration of findings


, : Prenatal and perinatal risk factors for autism: a review and integration of findings. Archives of Pediatrics & Adolescent Medicine 161(4): 326-333

Objective: To review the evidence for the presence of prenatal and perinatal factors that affect the risk of autism and autism spectrum disorders.Data Sources: Relevant articles were identified by searching MEDLINE, screening reference lists of original studies, and searching major journals likely to publish epidemiological studies on the topic.Study Selection: For inclusion in this review, studies required (1) a well-defined sample of cases drawn from population-based registers or cohorts; (2) standardized, prospectively collected obstetric information from birth records or registers; (3) comparison subjects drawn from the general population with information on obstetric complications collected from the same source; and (4) a standardized format for presentation of data, allowing for comparisons among studies.Main Exposures: Parental characteristics and obstetric complications.Main Outcome Measures: Rates of autism and autism spectrum disorders.Results: Seven epidemiological studies were identified that fulfilled inclusion criteria. The parental characteristics associated with an increased risk of autism and autism spectrum disorders included advanced maternal age, advanced paternal age, and maternal place of birth outside Europe or North America. The obstetric conditions that emerged as significant fell into 2 categories: (1) birth weight and duration of gestation and (2) intrapartum hypoxia.Conclusions: Evidence to suggest that parental age and obstetric conditions are associated with an increased risk of autism and autism spectrum disorders is accumulating. Although not proven as independent risk factors for autism, these variables should be examined in future studies that use large, population-based birth cohorts with precise assessments of exposures and potential confounders.

US$19.90

PMID: 17404128

DOI: 10.1001/archpedi.161.4.326


Other references

Wyand, R.C.; Yang, T.J., 1981: T and B lymphocyte levels in the peripheral blood of dogs affected with cyclic neutropenia. Canine cyclic neutropenia (CN), a heritable disease of Collie dogs, is characterized by the periodic cycling of formed elements of blood and the near disappearance of neutrophils every 11-12 days. Studies suggest that lymphocyte activity and regul...

Rigbey, L., 1983: The TFA's formative year. The Tenant Farmers' Association was set up in the UK in 1981 intended as a "crutch" for the ailing landlord and tenant system. The article suggests the association also brings immediate benefits to land agents and that even tenants...

Punam Dahiya; Juneja, I.J.; Singh, M.P.; Sanjay Kumar, 1996: Effect of provision of bedding on the growth performance of female buffalo calves during winter season. 20 female buffalo calves, 5-10 months of age, were loose housed with (T2) or without bedding (T1) for 105 days during the winter. Calves in the T2 group gained 8% more body weight compared with those in the T1 group (not sig.). Average daily nutri...

Duncan, M.B.; Kalluri, R., 2009: Parstatin, a novel protease-activated receptor 1-derived inhibitor of angiogenesis. Angiogenesis, the process of forming new blood vessels, is a well established and clinically relevant feature of a variety of disease states. Whether blood vessels sprout in a given tissue environment depends on the balance between factors that st...

Rajendra Prasad; Power, J.F., 1997: Soil fertility management for sustainable agriculture. Various aspects of soil fertility problems of developing countries, including both temperate and tropical zones are described and discussed in the 20 chapters of this book. The chapters are entitled: introduction; essential plant nutrients; soil,...

Ulger, Z.; Ozyurek, A.Ruhi.; Levent, E., 2005: Unusual cranial magnetic resonance imaging findings in a case with Sydenham's chorea. Pediatrics International 46(6): 745-747

Anonymous, 1993: Health reform: what it could cost the lodging industry. The lodging industry has a large stake in any health care reform that leads to universal coverage, because it employs a large number of part-time workers who are currently not covered, and because the industry's low average wages make health...

Cerletti, P.; Bucci, E.; Lpata, P., 1959: De-phosphorylation and deamination of adenosine and inosine derivatives and glucose amination in the bone marrow. The dephosphoryla-tion and deamination of hypoxanthine and adenine nucleotides and nucleo-sides has been separately studied in preparations of bone marrow of the epiphyseal and metaphyseal spongiosa and of the diaphyseal channel. A stronger dephos...

Venugopal, P.Dilip, 2010: An updated and annotated list of Indian lizards Reptilia Sauria based on a review of distribution records and checklists of Indian reptiles. Over the past two decades many checklists of reptiles of India and adjacent countries have been published. These publications have furthered the growth of knowledge on systematics, distribution and biogeography of Indian reptiles, and the field of...

Coimbra, A.; Delgado, J.L.; Moreira Silva, J.P.; Rodrigues, J.; Castel Branco, M.G.; Vaz, M., 1999: Retrospective analysis of hymenoptera venom skin tests and venom specific IgE antibodies. Journal of Allergy & Clinical Immunology 103(1 PART 2): S165, Jan