geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Teleosts as models for human vertebral stability and deformity


, : Teleosts as models for human vertebral stability and deformity. Comparative Biochemistry and Physiology. Toxicology & Pharmacology 145(1): 28-38

Vertebral development is a dynamic and complicated process, and defects can be caused by a variety of influences. Spinal curvature with no known cause (idiopathic scoliosis) affects 2-3% of the human population. In order to understand the etiology and pathogenesis of complex human skeletal defects such as idiopathic scoliosis, multiple models must be used to study all of the factors affecting vertebral stability and deformity. Although fish and humans have many of the same types of offenses to vertebral integrity, they have been overlooked as a resource for study. The most common morphological deformity reported for fish are those that occur during the development of the spinal system, and as with humans, curvature is a common morphological consequence. Here we review spinal curvature in teleosts and suggest that they are an unexploited resource for understanding the basic elements of vertebral stability, deformity, development and genetics. Fish can be a value to vertebral research because they are tractable, have a diversity of non-induced vertebral deformities, and substantial genomic resources. Current animal models lack non-induced deformities and the experimental tractability necessary for genetic studies. The fact that fish are free of an appendicular skeleton should allow for analysis of basic spinal integrity without the biomechanical constraints observed in quadrupedal and bipedal models. To illustrate the point we review human idiopathic scoliosis and the potential contribution teleosts can make for the identification of causes, risk factors, and treatment options.

US$19.90

PMID: 17240199

DOI: 10.1016/j.cbpc.2006.10.004


Other references

Máca, I.F., 1976: Air conditioning of the modern textile plants. Gesundheits-Ingenieur 97(6): 132-142

Olivier, A.R.; Thomas, G., 1990: Three forms of phosphatase type 1 in Swiss 3T3 fibroblasts. Free catalytic subunit appears to mediate s6 dephosphorylation. The major 40 S ribosomal protein S6 phosphatase in Swiss mouse 3T3 fibroblasts is a type 1 enzyme (Olivier, A. R., Ballou, L. M., and Thomas, G. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 4720-4724). Polyclonal antibodies were raised against a syn...

Kim, K.Ho.; Lee, J.Man.; Zhou, Y.; Harpavat, S.; Moore, D.D., 2016: Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. Liver fibrosis is a reversible wound-healing process that is protective in the short term, but prolonged fibrotic responses lead to excessive accumulation of extracellular matrix components that suppresses hepatocyte regeneration, resulting in per...

Dietz L.D.; Johnson C.E.; Ellsworth W.L.; Bogaert B.M.; Bittenbinder A.N.; Kohler W.M., 1997: Recent improvements to Earthworm; the associator. Seismological Research Letters 68(2): 331-332

Haq, MA.; Ramani, N., 1984: Population ecology of microarthropods in relation to vegetation and rainfall. International Congress of Entomology Proceedings, 17: 297

Liu, W.; da Silva, G.F.Z.; Wu, G.; Palmer, G.; Tsai, A-Lim.; Kulmacz, R.J., 2011: Functional and structural roles of residues in the third extramembrane segment of adrenal cytochrome b561. Several residues in the third extramembrane segment (EM3) of adrenal cytochrome b(561) have been proposed to be involved in this cytochrome's interaction with ascorbate, but there has been no systematic evaluation of residues in the segment....

Reisinger, Ludwig, 1926: An interesting defect in the eye of an owl. An owl (Athene noctula) with an iris coloboma in the left eye had normal light reflexes in the right eye but weak reflexes in the left, presumably because of the defect which involved the m. sphincter pupillae.

Dereuddre, J.T.nnoury, M., 1995: Cryopreservation of germplasm of carnation (Dianthus caryophyllus L.). Cryopreservation of plant germplasm I 477

Uemoto, K.; Ogata, K.; Mebrahtu, Y., 1977: Black flies diptera simuliidae of ethiopia part 1 on 4 new and 3 uncertain species of simulium. S. (Pomeroyellum) awashense sp. nov., S. (Metomphalus) gibense sp. nov., S. (M.) dawaense sp. nov., S. (M.) jimmaense sp. nov., S. (Pomeroyellum) sp. "Ethiopian A", S. (Pomeroyellum) sp. "Ethiopian B" and S. (Pomeroyellum) sp....

Sly, M.M.; Moore, B.Keith.; Platt, J.A.; Brown, C.E., 2007: Push-out bond strength of a new endodontic obturation system (Resilon/Epiphany). Endodontic sealers should demonstrate adhesive properties to dentin to reach the objectives of the obturation of the canal space and seal the canal space both apically and coronally, thus decreasing the chance of endodontic treatment failure. Adhe...