+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

CpG oligodeoxynucleotides allow for effective adoptive T-cell therapy in chronic retroviral infection

, : CpG oligodeoxynucleotides allow for effective adoptive T-cell therapy in chronic retroviral infection. Blood 109(7): 2982-2984

Adoptive T-cell therapy in cancer or chronic viral infections is often impeded by the development of functional impairment of the transferred cells. To overcome this therapeutic limitation we combined adoptive transfer of naive, virus-specific CD8(+) T cells with immunostimulative CpG oligodeoxynucleotides (ODNs) in mice chronically infected with the Friend retrovirus. The CpG-ODN co-injection prevented the T cells from developing functional defects in IFN gamma and granzyme production and degranulation of cytotoxic molecules. Thus, the transferred T cells were able to reduce chronic viral loads when combined with CpG-ODNs. This strategy provides a new approach for developing successful adoptive T-cell therapy against chronic infections.


Other references

Liebel, H.T.; Gebauer, G., 2011: Stable isotope signatures confirm carbon and nitrogen gain through ectomycorrhizas in the ghost orchid Epipogium aphyllum Swartz. Epipogium aphyllum is a rare Eurasian achlorophyllous forest orchid known to associate with fungi that form ectomycorrhizas, while closely related orchids of warm humid climates depend on wood- or litter-decomposer fungi. We conducted (13) C and (...

Ross, B.; Tran, T.; Bhattacharya, P.; Watterson, D.Martin.; Sailasuta, N., 2011: Application of NMR spectroscopy in medicinal chemistry and drug discovery. We describe the details of the magnetic resonance spectroscopy and chemical shift imaging techniques for the human brain which have been developed over the last two decades. With these non-invasive tools, it is now readily possible to repeatedly a...

Walsh, J.J.; Foley, C.; Bennett, J., 1992: Using the toxic release inventory to identify firms for technical assistance. Proceedings of the Technology Transfer Society Annual Meeting International Symposium and exhibit: 7th) 184-190

Schmidt, T.; Adam, C.; Hirsch, H.H.; Janssen, M.W.W.; Wolf, M.; Dirks, J.; Kardas, P.; Ahlenstiel-Grunow, T.; Pape, L.; Rohrer, T.; Fliser, D.; Sester, M.; Sester, U., 2015: BK polyomavirus-specific cellular immune responses are age-dependent and strongly correlate with phases of virus replication. BK polyomavirus (BKPyV) infection is widespread and typically asymptomatic during childhood, but may cause nephropathy in kidney transplant recipients. However, there is only limited knowledge on BKPyV-specific immunity in children and adults, and...

Logusch, E.W.; Walker, D.M.; Mcdonald, J.F.; Franz, J.E., 1994: Cyclic P-glycosidic phosphinothricin analogues as glutamine synthetase inhibitors and herbicides. Abstracts of Papers American Chemical Society 207(1-2): AGRO 45

Jiang, W.; Liu, D., 1999: Effects of PB2+ on root growth, cell division, and nucleolus of Brassica juncea L. The effects of different concentrations (10-5-10-2 M) of lead nitrate on root growth and nucleoli in root tip cells of Brassica juncea L. were investigated. The results showed that lead nitrate has a stimulatory effect on root growth at lower conc...

Min, B.M.; Kim, S.Y., 1997: Muscle clamping system as new strabismus surgery. Investigative Ophthalmology & Visual Science 38(4 PART 1-2): S113

Greeff, I.L.; Visser, J.A.; Ptasinski, K.J.; Janssen, F.J.J.G., 2003: Integration of a turbine expander with an exothermic reactor loop - flow sheet development and application to ammonia production. This paper investigates the direct integration of a gas turbine power cycle with an ammonia synthesis loop. Such a loop represents a typical reactor-separator system with a recycle stream and cold separation of the product from the recycle loop. T...

McDonald, A.L.; Fielder, R.J.; Diggle, G.E.; Tennant, D.R.; Fisher, C.E., 1996: Carcinogens in food: priorities for regulatory action. A pragmatic possible approach to the prioritization of chemical carcinogens occurring as food contaminants is described, based on the carcinogenic risk to the population. This should be of value in ensuring that resources for assessment and manage...

Wehri, K., 2013: Compliance with monthly billing requirement for hospices. Caring 32(2): 54-54