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Is vegetable annatto butter colour cancrogenic?

, : Is vegetable annatto butter colour cancrogenic?. Acta Pathologica et Microbiologica Scandinavica 37(6): 483-491

A series of experiments with rats and mice to test the possible cancerogenicity of the Danish vegetable annatto butter-color. Equal numbers of animals were used for tests and controls, which included feeding of both types, painting of mouse skin, and subcutaneous injections in mice. Oral administration of annatto proved to be non-cancerogenic for mice and rats. Mice painted with a solution of annatto in benzene produced no cancerogenic effects on the epidermis. Subcutaneous injections caused some sarcomas at the site of injection. Application of the Chi2 test to the data led to the conclusion that annatto had no influence on the development of leukemia. The number of pulmonary tumors in female mice did increase following treatment with annatto, but the authors conclude that the annatto is non-cancerogenic.


PMID: 13301727

DOI: 10.1111/j.1699-0463.1955.tb00973.x

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