+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Quantitative Study Of Collagen Content In Experimental Cirrhosis

, : Quantitative Study Of Collagen Content In Experimental Cirrhosis. Journal of Experimental Medicine 85(3): 217-226

Quantitative determinations of collagen were carried out on rat livers showing cirrhosis due to p-dimethylaminoazobenzene and carbon tetrachloride. A twofold increase in collagen content occurred in cirrhosis due to p-dimethylaminoazobenzene. The average total hepatic collagen as well as the per cent collagen content were doubled. The collagen content after 1(1/2) months of normal diet had fallen to normal levels. In cirrhosis due to carbon tetrachloride, the collagen content underwent about a fourfold increase. Partial reversal with significant decrease in collagen content occurred after stopping the carbon tetrachloride. The incomplete resorption of collagen in this group can be attributed to impaired hepatic regeneration following the prolonged administration of the compound. The chemical values for collagen parallel the quantitative evaluations of collagen content, based on microscopic examination of liver sections stained for reticulum. Deposition of collagen in hepatic cirrhosis is not necessarily an irreversible phenomenon.


PMID: 19871609

DOI: 10.1084/jem.85.3.217

Other references

Kipnis, Vm, 1980: Change in the qualitative composition of humus in Solonetz soils as a result of application of ferrous sulfate heptahydrate. Teoreticheskie osnovy i opyt meliorativnoi obrabotki i khimicheskoi melioratsii solontsovykh pochv: tezisy dokladov na Vsesoiuznom nauchno tekhnicheskom soveshchanii 24-28 iiunia 1980 g p Shortandy: 116

Arikan, S.; Paetznick, V.; Rex, J.H., 2002: Comparative evaluation of disk diffusion with microdilution assay in susceptibility testing of caspofungin against Aspergillus and Fusarium isolates. We compared the disk diffusion and broth microdilution methods for susceptibility testing of caspofungin against Aspergillus (n=78) and Fusarium (n=22) isolates. Microdilution testing followed the NCCLS M-38P guidelines but was performed in antibi...

Konini, A.; Kang, M.; Moghadas, S.M., 2016: Simulating Immune Interference on the Effect of a Bivalent Glycoconjugate Vaccine against Haemophilus influenzae Serotypes "a" and "b". Objective. We sought to evaluate the immune responses to a bivalent Haemophilus influenzae glycoconjugate vaccine against serotypes "a" (Hia) and "b" (Hib) in the presence of the preexisting immunity to Hib. Methods. We develop...

Jackson, D.J., 1934: Parasites of Weevils of the Genus Sitona. Further parasites of weevils of the genus Sitona observed by the author are a Tachinid larva from S. hispidula, F., from Ontario, and Protozoa of the genus Mycetosporidium from 5. hispidula, a Microsporidian and a Mermithid from S. lineata, L., an...

Spoendlin, H., 1965: Structural properties of the vestibular receptors. Schweizer Archiv für Neurologie, Neurochirurgie und Psychiatrie 96(2): 219-230

Yamaue H.; Tanimura H.; Tsunoda T.; Iwahashi M.; Tani M.; Tamai M., 1990: Basic analysis and clinical efficacy of il 2 activated tumor infiltrating lymphocytes in cancer therapy. Journal of Cancer Research & Clinical Oncology 116(SUPPL PART 1): 330

Chandrashekar, J.; Thankappan, K.R.; Sundaram, K.R., 2011: Severe dental fluorosis and jowar consumption in Karnataka, India. Dental fluorosis is a major public health problem in 17 states of India. Earlier studies have reported that Jowar (a type of millet) consumption interacts with fluoride (F) in the body and enhances fluorosis. We conducted this study to determine t...

Wong I.G., 1984: The Colorado Lineament; problems in defining seismic source zones. Earthquake Notes 55(3): 10

Scholl, T.O.; Hediger, M.L.; Huang, J.; Johnson, F.E.; Smith, W.; Ances, I.G., 1992: Young maternal age and parity. Influences on pregnancy outcome. The authors explored the influence of young maternal age and parity upon pregnancy outcome in a cohort of almost 887 adolescents and mature women from Camden, New Jersey. Primigravid primiparas aged 12-15 years were compared with mature primigravi...

Chatterjee, D.; Hunter, S.W.; McNeil, M.; Brennan, P.J., 1992: Lipoarabinomannan. Multiglycosylated form of the mycobacterial mannosylphosphatidylinositols. The lipopolysaccharides of mycobacteria, lipoarabinomannan (LAM) and lipomannan (LM), of key importance in host-pathogen interaction, were recently shown to contain a phosphatidylinositol "anchoring domain." We now have established that...