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Effect of vitamin B12 and intrinsic factor in producing normal haemopoiesis. Study of human haemopoietic tissue cultures in vitro and of the haemopoietic tissue of the chick embryo


, : Effect of vitamin B12 and intrinsic factor in producing normal haemopoiesis. Study of human haemopoietic tissue cultures in vitro and of the haemopoietic tissue of the chick embryo. Sang. 31: 323-329

When marrow tissue from 5 patients with pernicious anaemia was incubated with large amounts of vitamin B12 the number of megaloblastic basophils decreased and that of erythroblasts increased. Simultaneous addition of intrinsic factor did not appreciably augment the effect of the vitamin. A study with chick embryos confirmed the effect of vitamin B12 by itself, but that effect was augmented by addition of intrinsic factor.

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