+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Some recent work on transplantation antigens

, : Some recent work on transplantation antigens. Biologica 31: 7-14

A description of certain characteristics of genes and antigens of histocompatibility, in tissue transplants of the rat, particularly those belonging to the H-2 system is given. Attention is called to the characteristic complexity of some antigen systems and it is postulated that this is a general property of the genes which determine them, and that in this way the tissues reach a considerable degree of antigenic individuality with a relatively low number of genes of histocompatibility. Different tissues possess different quantities of these antigens and some, like the cerebrum, testicle, and muscles possess none. H-2 antigens of certain strains of rats are not present in the newly born. They begin to appear after 2 or 3 days and reach the adult concentration about the first week. Comparing the H-2 antigens in homogenized preparation of various rat organs, suspended in water or saline solutions, it has been shown that the supernatants of the material centrifuged from the spleen, in contrast with those from the other organs, contained appreciable quantities of H-2 antigens. There were no differences in these antigens in the remains of the spleen, liver of lymphatic ganglia. All the antigens of the sediment, like those of the supernatant, had the same specificity. These discoveries, perhaps, explain the differences in the primary response of circulating anti H-2 antibodies, induced by the spleen and lyophilized liver. The significance of these findings is discussed in relation to various problems of general immunology and especially to the theory of immunological recognition of the "foreign".


PMID: 13907997

Other references

Hughes, R.; Griffiths, D.J., 1956: The influence of sward composition and sward management on the following oat crop. The paper is a contribution to a knowledge of the precise effects of ley management, manuring and seeds mixtures on the following crop. This was a fenced plot experiment in which a 5-year ley, which had been subject to different systems of managem...

Quintana, R.P.; Lasslo, A.; Dugdale, M.; Goodin, L.L.; Burkhardt, E.F., 1980: Effects of ethanol and of other factors on ADP-induced aggregation of human blood platelets in vitro. Thrombosis Research 20(4): 405-415

Castell, J.A.; Castell, D.O., 1997: Recent developments in the manometric assessment of upper esophageal sphincter function and dysfunction. Coordinated application of videoradiography and solid-state manometry provides insight into the pathophysiology of oropharyngeal dysphagia and helps direct appropriate therapies for a variety of conditions causing this symptom. Controlled evaluati...

Berthold-Godefroy, N.; Wolff, R., 1958: Intestinal absorption of cholesterol-4-14C in the rat and the effect of sitosterol. When cholesterol-4-14C was given in cottonseed oil to normal rats about 70 per cent. was absorbed; when the cholesterol was given with excess sitosterol, only 56 per cent.G. A. Garton.

Canlorbe P.; Chartier M., 1968: Pathological puberties part 5 diagnosis of pubertal retardation in the girl. Feuillets du Praticien 33(12): 665-666

Nemec, S.J.; Adkisson, P.L., 1966: Comparative effectiveness of low volume concentrate and water emulsion sprays of certain insecticides for cotton insect control. The following is virtually the authors' summary. In tests in the laboratory in Texas, low-volume sprays of certain undiluted concentrated insecticides were as effective as conventional water emulsion sprays for killing the larvae of Heliothis...

Novgorodova M.I.; Generalov M.Y.; Gorshkov A.I.; Sivtsov A.V.; Uspenskiy Y.I., 1991: Native gold and bismuth carbonate and tellurate associations. Izvestiya Akademii Nauk SSSR Seriya Geologicheskaya

Thorpe, R.S., 1976: Biometric analysis of geographic variation and racial affinities. Biological Reviews of the Cambridge Philosophical Society 51(4): 407-425

Gómez-Batiste, X.; Mateo-Ortega, D.; Lasmarías, C.; Novellas, A.; Espinosa, J.; Beas, E.; Ela, S.; Barbero, J., 2016: Enhancing psychosocial and spiritual palliative care: Four-year results of the program of comprehensive care for people with advanced illnesses and their families in Spain. We aimed to describe the overall quantitative and qualitative results of a "La Caixa" Foundation and World Health Organization Collaborating Center Program entitled "Comprehensive Care for Patients with Advanced Illnesses and their...

Bressler J.P.; Weingarten D.; Kornblith P.L., 1985: Glucocorticoid mediated increases in glycerol phosphate dehydrogenase activity in inhibited by the phorbol ester tumor promoters. An oligodendroglial specific property, glucocoticoid regulation of glycerol-3-phosphate dehydrogenase (GPDH) levels, was inhibited in C6 rat glioma cells when 4.beta.-phorbol 12-mryistate 13-acetate (PMA) was added to the cultures. PMA inhibited G...