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The protective role of Scoparia dulcis on tissue antioxidant defense system of rats exposed to cadmium

, : The protective role of Scoparia dulcis on tissue antioxidant defense system of rats exposed to cadmium. African Journal of Biotechnology 6(10): 1192-1196

The possible antioxidant property of aqueous extract of Scoparia dulcis was tested in rats exposed to cadmium. Different groups of animals were treated with CdCl2 alone or in combination with graded levels of S. dulcis ( i.e. 250, 500 and 1000 mg/kg body wt, respectively). Cadmium, a known prooxidant was administered subcutaneously ( 3 mg/kg body wt), once every week, for two weeks. The required dose of aqueous extract of S. dulcis was administered daily for 2 weeks by gavage. The results show that relative to controls, cadmium significantly ( P < 0.05) reduced superoxide dismutase activity while significantly ( P < 0.05) increasing catalase activity and malondialdehyde levels in the liver and kidney. However, no significant effect was observed in the antioxidant enzyme activities and MDA levels in the heart. The dose of 1000 mg S. dulcis/kg body wt, like cadmium when administered alone, exhibited a prooxidant effect but when coadministered with cadmium, the high dose of S. dulcis effectively restored the antioxidant enzyme activities in the kidney and liver to levels that are not statistically different from the control. These observations show that aqueous extract of S. dulcis possesses significant antioxidant activity, sufficient to mitigate against free radical induced oxidative stress in experimental cadmium intoxication in the rat.


Other references

Hughes, P.; Hughes, B., 1988: Notes on berry and petal display by the red-backed wren at Widgee, south-east Queensland. Sunbird, 182: 52-53

Tomlin, A.; Martin, I., 2003: Registered and unregistered patients in general practice: implications for primary health organisations. To describe differences between registered and unregistered patients in New Zealand general practice and assess patient registers prior to enrollment in primary health organisations (PHOs). Patient records from 35 computerised general practices ma...

Addy, Nd, 1985: Biotechnology, what is the big deal?. Proceedings Western Society of Weed Science8(38): 17-20

Li-Korotky, H-Sheng.; Swarts, J.Douglas.; Hebda, P.A.; Doyle, W.J., 2004: Cathepsin gene expression profile in rat acute pneumococcal otitis media. Acute otitis media, often caused by infection with Streptococcus pneumoniae, is characterized by inflammation of the middle ear mucosa. A prominent feature of the host response to bacterial infection of the middle ear mucosa is an influx of inflam...

Bielawski R., 1975: Results of the zoological investigations of z kaszab in mongolia part 352 coccinellidae part 5 and part 6 coleoptera. Fragmenta Faunistica (Warsaw) 20(16): 247-271

Shin, N-Ri.; Jung, M-Ja.; Kim, M-Soo.; Roh, S.Woon.; Nam, Y-Do.; Bae, J-Woo., 2012: Corynebacterium nuruki sp. nov., isolated from an alcohol fermentation starter. A novel Gram-positive, strictly aerobic and non-motile bacterial strain, S6-4<sup>T</sup>, was isolated from a Korean alcohol fermentation starter. Optimal growth occurred at 37 °C, at pH 8 and in 1 % (w/v) NaCl. The isolate was po...

Yasnosh V.A., 1974: New species of eretmocerus hymenoptera aphelinidae from the georgian ssr ussr. Soobshcheniya Akademii Nauk Gruzinskoi SSR 73(3): 713-716

Bolle, C.S.pory, S.L.bberstedt, T.K.osgen, R.; Herrmann, R.; Oelmuller, R., 1994: The role of plastids in the expression of nuclear genes for thylakoid proteins studied with chimeric beta-glucuronidase gene fusions. We have analyzed plastid and nuclear gene expression in tobacco seedlings using the carotenoid biosynthesis inhibitor norflurazon. mRNA levels for three nuclear-encoded chlorophyll-binding proteins of photosystem I and photosystem II (CAB I and II...

Pollack, R.M.; Brothers, P.N.; Qi, L.; Blotny, G., 1995: An active site phenylalanine of 3-oxo-DELTA-5-steroid isomerase is important for proton transfer. FASEB Journal 9(6): A1265

Murphy, B.L.; Glasgow, A.; Ubl, D.S.; Habermann, E.B.; Lemaine, V., 2017: Surgical Treatment of Adolescent Breast Disorders: Institutional Experience and National Trends. Adolescent breast disorders are rare and typically benign in nature; however, surgical treatments may require multiple operations. Due to the limited existing data, we sought to evaluate national trends and describe our institutional experience to...