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The response of susceptible chickens to graded doses of the virus of visceral lymphomatosis

, : The response of susceptible chickens to graded doses of the virus of visceral lymphomatosis. Poultry Sci 35(1): 17-26

A study involving 1458 South Carolina White Leghorn chickens was made of the relation between the dose of the virus of visceral lymphomatosis (VL) and the response of the chickens over periods of 200 and 270 days when the material was given by the intraperi-toneal route. Filtered plasma and lymphomatous liver filtrates from strain RPL 12 inoculated birds were the inoculums used in graded doses in 4 experiments. The primary response was the development of VL. Deaths occurred as early as 22 days after inoculation in a high dosage lot and continued in the low dosage lots for as long as the chickens were kept. Range in incidence was from a low of 55.5% in a low dosage lot to a high of 90.1% in a high dosage lot, with an average age at death of 128.2 and 55.6 days in the same lots, respectively. In the intermediate dosage range, increases in dose caused step-wise increase in percentage of VL that occurred in 200 days but increases were small for each 10-fold increase in dose. A greater rate of change was noted in the average age at death which decreased rapidly with increases in dose. Based on the microscopic location of neoplastic cells, all cases of VL were classified into 1 of 2 types; namely intravascular or extravascular. The percentage of intravascular VL increased rapidly with an increase in dose but incidence of extravascular was inversely related to dose. A low but significant percentage of osteopetrosis also occurred in all inoculated lots. A consistent relation between dose and incidence of this bone disease was not obtained in 3 experiments, and an apparent inverse relation with dose was obtained in 1 experiment. Females were slightly more susceptible to VL, whereas males were slightly more susceptible to osteopetrosis.


DOI: 10.3382/ps.0350017

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