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Variations in uptake and excretion of radioiodine in the rat following different modes of administration


, : Variations in uptake and excretion of radioiodine in the rat following different modes of administration. Journal of Endocrinology 13(4): 354-359

The variations in uptake and excretion of radio-iodine after intraperitoneal, intraven., intramuscular and subcutaneous injection as well as oral administration with empty stomach, and full stomach, were investigated. 252 rats, divided into groups of 6, were used. Approximately 20 [mu]c in 0.2 cc of a solution of carrier-free I131 was given to each rat. For the uptake study the rats were killed at intervals of 1,2,4,24,48,96 and 192 hours. The rate of excretion of I131/day in urine was followed in the same rats used for the study of uptake, only 4 of 6 in each group being used. There is significant difference in the uptake of I131 only during the first hours after administration. The maximum uptake of I131 occurs within 24 hours and is independent of the mode of administration. There is no significant difference in the uptake of I131 after 24 hr. Excretion of I131 in the urine showed no significant difference.

US$19.90

PMID: 13345949

DOI: 10.1677/joe.0.0130354


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