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Sjogren's syndrome and adult celiac disease


, : Sjogren's syndrome and adult celiac disease. Gastroenterology 48(6): 869-876

A patient with Sjogren's syndrome, nutritional deficiencies, and diarrhea was shown to have primary intestinal malabsorption caused by adult celiac disease. Abnormalities of small intestinal mucosal function and morphology improved after treatment with a gluten-free diet. Studies with the I131-labeled human serum albumin-Amberlite XE-67(Cl-) technique demonstrated that prior to therapy there was abnormally low total body albumin, increased intestinal catabolism of albumin, and failure of the liver to increase sufficiently the rate of synthesis. These abnormalities of albumin metabolism disappeared following treatment with the gluten-free diet. Instillation of gliadin (purified wheat protein) into the jejunum after regeneration of the mucosa had occurred caused a severe histological reaction and a generalized urticarial skin eruption. Studies with fluorescein labeled antibody demonstrated increased gamma globulin deposition in the lamina propria of the jejunal mucosa.

US$29.90

PMID: 14300178


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