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Unimpaired Learning Ability Of Rats Made Artificially Phenylketonuric During Fetal Or Neonatal Life

, : Unimpaired Learning Ability Of Rats Made Artificially Phenylketonuric During Fetal Or Neonatal Life. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 119: 282-287

Rats made artificially phenylketonuric during fetal or early neonatal life by the administration of large amounts of phenylalanine showed no defect in learning ability when tested later for capacity to acquire visual discrimination. Administration of large amounts of 5-hydroxytryptophan failed to correct the low brain serotonin concentrations characteristic of artificial phenylkeotnuria. The results of this investigation do not provide support for the thoery that a serotonin deficiency in brain during infancy causes the mental defect characteristic of human phenylketonuria. In addition, it appears unlikely that the rat is a suitable experimental animal for exploring the exact mechanism of the mental defect of phenylketonuria in man.


PMID: 14297871

DOI: 10.3181/00379727-119-30159

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