geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Analysis of the Saccharomyces cerevisiae exosome architecture and of the RNA binding activity of Rrp40p


, : Analysis of the Saccharomyces cerevisiae exosome architecture and of the RNA binding activity of Rrp40p. Biochimie 89(5): 686-691

The exosome is a complex of eleven subunits in yeast, involved in RNA processing and degradation. Despite the extensive in vivo functional studies of the exosome, little information is yet available on the structure of the complex and on the RNase and RNA binding activities of the individual subunits. The current model for the exosome structure predicts the formation of a heterohexameric RNase PH ring, bound on one side by RNA binding subunits, and on the opposite side by hydrolytic RNase subunits. Here, we report protein-protein interactions within the exosome, confirming the predictions of constituents of the RNase PH ring, and show some possible interaction interfaces between the other subunits. We also show evidence that Rrp40p can bind RNA in vitro, as predicted by sequence analysis.

US$19.90

PMID: 17391830

DOI: 10.1016/j.biochi.2007.01.011


Other references

Bukowiecki, H.; Zarebska, I., 1966: Structure of the vegetative organs of the species Ranunculus lanuginosus L. and of some ranunculi plants with antibiotic activity. Acta Poloniae Pharmaceutica 23(2): 159-162

Gopal, S.; Garibaldi, S.; Goglia, L.; Polak, K.; Palla, G.; Spina, S.; Genazzani, A.R.; Genazzani, A.D.; Simoncini, T., 2012: Estrogen regulates endothelial migration via plasminogen activator inhibitor (PAI-1). Endothelial plasminogen activator inhibitor (PAI-1) controls vascular remodeling, angiogenesis and fibrinolysis. PAI-1 blood levels in women are related to estrogen. The aim of this study was to characterize the signaling pathways through which es...

Marcason, W., 2008: Where can I find information and resources for the School Breakfast Program?. Journal of the American Dietetic Association 108(9): 1580-1580

Palfi, D.; Szentesi, A., 1975: Field experiments on bean weevil (Acanthoscelides obtectus) control by the release of sterile adults. The sterile insect release method was not effective for bean weevil control in Hungary because the majority of females leave the stores having already mated with normal males.

Coyle, D.R.; Coleman, M.D.; Durant, J.A.; Newman, L.A., 2006: Survival and growth of 31 Populus clones in South Carolina. Populus species and hybrids have many practical applications, but clonal performance is relatively undocumented in the southeastern United States outside of the Mississippi River alluvial floodplain. In spring 2001, 31 Populus clones were planted...

Shaffer, H.Bradley.; Pauly, G.B.; Oliver, J.C.; Trenham, P.C., 2004: The molecular phylogenetics of endangerment: cryptic variation and historical phylogeography of the California tiger salamander, Ambystoma californiense. A primary goal of conservation genetics is the discovery, delimitation and protection of phylogenetic lineages within sensitive or endangered taxa. Given the importance of lineage protection, a combination of phylogeography, historical geology and...

Van Bever, H.; Benoit, Y.; Delbeke, M.J.; Orye, E., 1985: Meningeal leukaemia in the blastic phase of chronic granulocytic leukaemia. A 51/2-year-old boy is presented with chronic granulocytic leukaemia and blastic transformation whose clinical course is complicated by meningeal leukaemia. In the authors' opinion prophylactic central nervous system therapy should be part of...

Zheng, X-Feng.; Zhao, E-Dian.; He, J-Ye.; Zhang, Y-Hui.; Jiang, S-Dan.; Jiang, L-Sheng., 2016: Inhibition of substance P signaling aggravates the bone loss in ovariectomy-induced osteoporosis. Substance P signaling regulates the functions of both osteoblast and osteoclast. Available reports on the effects of substance P on bone mass are contradictory. The objective of this study was to determine the change of substance P expression in t...

Catayee, G.; Senelar, R.; Chalet, M.; Kochoyan, Y., 1975: Changes induced with cyclophosphamide in the lympho-reticular elements with specific enzymatic activities of the splenic white pulp in rats and guinea-pigs. The effect of cyclophosphamide, one potent immunosupressor drug, was used to differenciate the behaviour of two types of Reticular cells, the phosphatasic acid and the 5'nucleotidasic cells. The first exhibit macrophagic and migratory propert...

Sapunar, F.; Catovsky, D.; Wotherspoon, A.; Matutes, E., 2000: Follicular lymphoma. A series of 11 patients with minimal or no treatment and long survival. Follicular lymphoma is the commonest low-grade lymphoma. Its indolent nature even in advanced stages and the failure of conservative or aggressive treatments to achieve a cure have questioned the need for immediate treatment. Eleven patients with...