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Chronic infections and genetic factors in the development of ischemic stroke


, : Chronic infections and genetic factors in the development of ischemic stroke. New Microbiologica 30(3): 213-220

The aim of this study was to examine whether chronic infections and genetic factors of the host play roles in the pathophysiology of acute noncardioembolic ischemic stroke. Blood samples from 59 subjects with ischemic stroke and 52 control patients were investigated by nested PCR for the presence of C. pneumoniae DNA, HCMV DNA and enterovirus RNA, by ELISA for the levels of antibodies to C. pneumoniae, HCMV, HSV, HHV-6, EBV and the inflammatory chemokine IL-8, and by PCR for promoter polymorphism of the IL-8 and CD14 host genes. Associations of stroke with the HCMV IgG and HSV-1 IgA antibody levels were observed. No association of stroke was detected with the presence of C. pneumoniae, HCMV or enterovirus nucleic acids in the peripheral blood, C. pneumoniae IgM, IgG and IgA, the HSV IgG, the EBV IgG, or HHV-6 IgG antibody levels, the pathogen burden, the IL-8 or CD 14 promoter polymorphisms, or with the serum levels of IL-8 in the overall study population. These results are consistent with the hypothesis that certain pathogens are involved in the development of ischemic stroke.

US$29.90

PMID: 17802898


Other references

Lidström, P.; Lindholmer, C.; Orinius, E., 1968: The late cardiac prognosis after non-penetrating chest trauma. Acta Medica Scandinavica 183(3): 243-244

Chu, G.; Chang, E., 1988: Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA. The disease xeroderma pigmentosum is characterized by deficient repair of damaged DNA. Fusions of cells from different patients have defined nine genetic complementation groups (A through I), implying that DNA repair in humans involves multiple ge...

Hagland, M., 1997: Putting a new SPIN (Sentara Physician Information System) on information systems. When was the last time you invested in your system's future?. Once you have a vision and strategy for the future, an information system will probably be your biggest and most important investment. Information systems that can track clinical data are critical to providing employers with the data they're...

Hamilton D.L.; Mackenzie W.S., 1960: Nepheline solid solution in the system NaAlSiO (sub 4) -KAlSiO (sub 4) -SiO (sub 2). "The limit of solid solution of SiO (sub 2) in nephelines has been determined at 700 degrees C and a water pressure of 15,000 lb/sq. in. X-ray data are given for the determination of the composition of nephelines in equilibrium with alkali fe...

Buchholz, R., 1984: Innovative consumption behavior on the food markets. The paper identifies innovative food consumers and their general behaviour as a way of predicting changes in food consumption in the GFR. Adopter categories are delimited for cereal products based on a random sample of 398 housewives in Hanover. T...

Filmer Paul E.; Kirschvink Joseph L., 1986: Magnetostratigraphy of the Upper Cretaceous Rosario Formation, northwestern Baja California, Mexico. Abstracts with Programs - Geological Society of America 18(2): 106

Antoniou, A.C.; Pharoah, P.D.; Day, N.E.; Ponder, B.J.; Easton, D.F., 2000: Models for familial breast cancer incorporating BRCA1, BRCA2 and other genes. Genetic Epidemiology 19(3): 236-237, October

Bowles, F.; Wells, H., 2011: Paronychia: not always what it seems. Emergency Medicine Journal 28(4): 342-342

Forey H.; Relke W.; Reinsch M., 1968: Methods of early diagnosis of hearing defects in children and questions dealing with the rehabilitation of hearing. Pamietnik Zjazdu Otolaryngologow Polskich w Katowicach : 1970

Glaser, R.; Hodgen, B.; Rayat, S., 2002: Nitrosative adenine deamination A theoretical study of the decomposition pathways of adeninediazonium ion. Abstracts of Papers American Chemical Society 223(1-2): COMP 258