+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens

, : Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Proceedings of the National Academy of Sciences of the United States of America 104(47): 18730-5

Fungi in the genus Malassezia are ubiquitous skin residents of humans and other warm-blooded animals. Malassezia are involved in disorders including dandruff and seborrheic dermatitis, which together affect >50% of humans. Despite the importance of Malassezia in common skin diseases, remarkably little is known at the molecular level. We describe the genome, secretory proteome, and expression of selected genes of Malassezia globosa. Further, we report a comparative survey of the genome and secretory proteome of Malassezia restricta, a close relative implicated in similar skin disorders. Adaptation to the skin environment and associated pathogenicity may be due to unique metabolic limitations and capabilities. For example, the lipid dependence of M. globosa can be explained by the apparent absence of a fatty acid synthase gene. The inability to synthesize fatty acids may be complemented by the presence of multiple secreted lipases to aid in harvesting host lipids. In addition, an abundance of genes encoding secreted hydrolases (e.g., lipases, phospholipases, aspartyl proteases, and acid sphingomyelinases) was found in the M. globosa genome. In contrast, the phylogenetically closely related plant pathogen Ustilago maydis encodes a different arsenal of extracellular hydrolases with more copies of glycosyl hydrolase genes. M. globosa shares a similar arsenal of extracellular hydrolases with the phylogenetically distant human pathogen, Candida albicans, which occupies a similar niche, indicating the importance of host-specific adaptation. The M. globosa genome sequence also revealed the presence of mating-type genes, providing an indication that Malassezia may be capable of sex.


PMID: 18000048

DOI: 10.1073/pnas.0706756104

Other references

van Donk, E.; Grimm, MP.; Gulati, RD.; Heuts, PGM. de Kloet, WA. van Liere, L., 1990: First attempt to apply whole-lake food-web manipulation on a large scale in the Netherlands. Lake Breukeleveen (180 ha, mean depth 1.45 m), a compartment of the eutrophic Loosdrecht lakes system, was selected to study the effects of whole-lake foodweb manipulation on a large scale. In Lake Loosdrecht (dominated by filamentous cyanobacteri...

Sokolov, M.; Pozdniakov, A., 1978: Use of different cell cultures for the isolation of the parainfluenza-3 virus from lambs. Biulleten' Vsesoiuznogo instituta eksperimental'noi veterinarii: 3) 48-51

Cram, W.J., 1974: The regulation of concentration and hydrostatic pressure in cells in relation to growth. The dependency of rate of expansion growth on turgor pressure is discussed, and the osmotica involved in maintaining internal osmotic and hydrostatic pressure and regulation of their concentrations via transport and biochemical conversions in vari...

Indriati Etty, 2004: Indonesian fossil hominid discoveries from 1889 to 2003; catalogue and problems. The number of Indonesian hominid fossil discoveries has increased from the first in 1889 up to 2003. The most recent publications of Indonesian's hominid discoveries were in 1975 and in 1984. While the 1975 catalogue listed 57 hominids from I...

Cabezalí, D.; Tordable, C.; Gómez, A., 2016: Pediatric urinary tract catheters. NlmCategory="UNASSIGNED">Urinary tract catheters are hollow and flexible tubes used to facilitate urine output or to achieve urine transit through them. We can find different types of catheters depending on the purpose they have been...

Siampoulos, K.C.; Elisaf, M.; Drosos, A.A.; Mavridis, A.A.; Moutsopoulos, H.M., 1992: Renal tubular acidosis in primary sjogren's syndrome. Renal tubular acidosis (RTA) is a frequent extraglandular manifestation of Sjogren's syndrome; however, no distinction on the incidence of this renal tubular defect between primary and secondary Sjogren's syndrome has been reported. This...

Keilbart, Martina, 2000: Social and medical consequences of the human genome project 20-21 February 1999, Landesmuseum fuer Technik und Arbeit, Mannheim, Germany. Functional & Integrative Genomics 1(2): 140-141, September

Bergman, S., 1963: Observations on the early life of TalegaUa and Megapodius in New Guinea. a Guinea (ZoolNo. 17: 347-354

Casey, N., 1997: The Royal College of Nursing Congress. Nursing Standard 1987) 11(35): 1-1

Fishman, N., 1979: Harold benge atlee. Canadian Medical Association Journal 121(11): 1439-1441