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Desirable performance standards for HbA(1c) analysis precision, accuracy and standardisation


, : Desirable performance standards for HbA(1c) analysis precision, accuracy and standardisation. Clinical Chemistry and Laboratory Medicine 45(8): 1083-1097

Background: HbA(1c) (glycohaemoglobin) is universally used in the ongoing monitoring of all patients with diabetes. There are many %HbA(1c) target control rating recommendations by national, regional and international expert bodies for diabetes patients and these are variable around the world. General patient target control ratings are currently most often recommended as either < 6.5% or < 7.0% HbA(1c) with < 6.0% HbA(1c) stated for individual patients where clinically possible. This necessitates very precise HbA(1c) assays and the same patient values, irrespective of HbA(1c) method or area of the world.Methods: HbA(1c) targets recommended by major expert groups and published HbA(1c) assay precision (coefficient of variation, %CV) levels have been detailed. These have been compared with published biological variation levels and with calculated HbA(1c) error ranges at various HbA(1c) levels and %CV levels. In addition, these have been compared with the analytical precision necessary to differentiate between the upper limit of the normal range for HbA(1c) and targets recommended by expert groups for diabetes control.Results: Intralaboratory analytical CVs of < 2% are necessary and are achievable on automated HPLC analysers, and are supported on grounds of both clinical need and biological variation, as well as the need to differentiate the national, regional and international target recommendations from the upper limit of the normal range (< 6.0% HbA(1c) level).Conclusions: Routine methods with tight long-term imprecision with CVs of < 2% are recommended. International HbA(1c) targets essentially require that all HbAlc methods be precise, and have minimal standardisation bias and minimal methodological interferences in individual patients.

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Other references

Hertz, R., 1960: The pharmacological alteration of the biosynthesis and the peripheral effects of steroid hormones. Acta Endocrinologica. Supplementum: 147-148

Maxwell, M.L., 1984: Innovations in teacher education in developing countries: a case study. Current research findings indicate that (1) the impact of innovations on educational settings is minimal, if any, and (2) few innovations are being institutionalized. This study examined issues surrounding the institutionalization of innovations,...

Kumar, M.; Kumar, A.; Maroules, M.; Abrina, V.; Kumar, V., 2016: Postmenopausal vaginal bleeding as initial presentation of gastric cancer: a case report with literature review of prognostic factors and treatment of krukenberg tumor. Postmenopausal vaginal bleeding is a rare presentation of Krukenberg tumor (KT). Here we report a very unusual presentation of gastric cancer in a postmenopausal female patient, who presented with complaint of vaginal bleeding. She was found to ha...

Bono, J.M.; Crespi, B.J., 2008: Cofoundress relatedness and group productivity in colonies of social iDunatothrips (Insecta: Thysanoptera) on Australian iAcacia. Facultative joint colony founding by social insects provides opportunities to analyze the roles of genetic and ecological factors in the evolution of cooperation. Although cooperative nesting is observed in range of social insect taxa, the most de...

Drummond B.J.; Goncharov A.G.; Collins C.D.N., 1997: Crustal structure in the Archaean and Proterozoic provinces in Australia. Record - Australian Geological Survey Organisation Pages 37-41

Bjorkman, M.; Hamback, P., A.; Ramert, B., 2007: Neighbouring monocultures enhance the effect of intercropping on the turnip root fly (Delia floralis). Knowledge of insect behaviour is essential for accurately interpreting studies of diversification and to develop diversified agroecosystems that have a reliable pest-suppressive effect. In this study, we investigated the egg-laying behaviour of t...

Schöpf, J.; Lemarchand, T., 1994: Lithium addition in endogenous depressions resistant to tricyclic antidepressants or related drugs: relation to the status of the pituitary-thyroid axis. Concentrations of TSH, TRH-induced TSH (DELTA-TSH), T4, FT4, T3, and FT3 were investigated in 20 patients resistant to antidepressants before and after one week of lithium addition. TSH and DELTA-TSH increased, whereas FT4 and FT3 decreased statis...

Duteau, J.; Guilloux, M.; Seguin, G., 1981: The influence of natural factors on grape maturation at Pomerol and Saint-Emilion in 1979. The vineyards of Pomerol and Saint-Emilion produce wines which differ according to the geological origin of the soil. Variations in mesoclimate are small and have little influence on wine quality. In 1979, a year of normal sunshine but low rainfal...

Chung, K-Sook.; Cho, S-Hee.; Shin, J-Sun.; Kim, D-Hyun.; Choi, J-Hye.; Choi, S.Y.; Rhee, Y.K.; Hong, H-Do.; Lee, K-Tae., 2013: Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. The triterpene saponin ginsenoside Rh2 has been shown to have antiproliferative effects on various cancer cells. However, the effect of Rh2 on the cell cycle and its underlying molecular mechanism in human leukemia cells are not fully understood....

Clay, T.P.; Hughes, J.M., 1978: Vagosympathetic attenuation of the broncho-constriction caused by pulmonary micro-embolism in the guinea-pig [proceedings. Journal of Physiology 282: 48p-49p