geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Do bladder cancer patients with metastatic spinal cord compression benefit from radiotherapy alone?


, : Do bladder cancer patients with metastatic spinal cord compression benefit from radiotherapy alone?. Urology 69(6): 1081-1085

Objectives To investigate the role of radiotherapy (RT) alone in metastatic spinal cord compression (MSCC) patients with bladder cancer.Methods Thirty-two MSSC patients with bladder cancer were included in this retrospective review. Potential prognostic factors were investigated for functional outcome, local control of MSCC, and survival: age, gender, performance status, visceral metastases at the time of RT, number of involved vertebrae, ambulatory status, time of developing motor deficits before RT, and radiation schedule (short-course RT [I week or less] versus long-course RT [2 to 4 weeks]).Results Two patients (6%) showed improvement of motor function, 25 (78%) no change, and 5 (16%) deterioration. Better functional outcome was significantly associated with a better performance status (P = 0.035). A trend was observed for absence of visceral metastases (P = 0.054). Five patients developed a recurrence of MSCC in the preirradiated spinal region, which was treated with reirradiation (0 improvement, 4 no change, I deterioration). Median survival was 4 months. The I-year survival rate was only 16%. Better survival was associated with absence of visceral metastases, being ambulatory, involvement of only one to three vertebrae, and better performance status.Conclusions Improvement of motor function was rare. For patients not suitable for decompressive Surgery, short-course RT seems preferable because it provides a functional Outcome similar to that with long-course RT and is more patient convenient. If the patient's prognosis seems extremely poor in terms of functional outcome and survival, single-fraction RT or even best supportive care may be considered.

US$19.90

PMID: 17572191

DOI: 10.1016/j.urology.2007.02.045


Other references

Arredondo Peter, R.; Bonic, A.; Sarath, G.; Klucas, R.V., 1995: Rapid PCR-based detection of inserts from cDNA libraries using phage pools or direct phage plaques and lambda primers. The use of a pair of lambda gt11 primers to amplify by PCR any insert DNA cloned into the EcoRI restriction site is described. DNA fragments were amplified and cloned using crude phage pools and direct phage plaques from a maize root cDNA library....

Zinovieva Nina G. (Zinov yeva Nina G); Mitreikina Olga B.; Granovsky Lev B., 1995: Specific pyroxene-olivine chondrules of the Yamato-82133 (H3) chondrite; evidence of the evolution of redox conditions during the chondrule formation. Papers Presented to the

Holthuis, L.B., 1964: The earliest published record of a cumacean. Crustaceana, 7: 317-318

Badenhop, M.B.; Wright, R.D., 1980: Costs and returns from producing an important shade tree: the pin oak. Information on production systems, cultural practices, physical facilities, and costs was obtained from successful operators of wholesale nurseries in Tennessee and Virginia. Fixed costs, variable costs, and gross returns/ha were studied (detailed...

Hoesch, W., 1960: The brooding behavior of the running chicken. The observations on T. s. lepurana published a year ago (Hoesch 1959) are considerably supple-mented through further observations on 3 caged pairs and their offspring. The female makes attempts to copulate particularly frequently after she has sta...

Lysiak, J.J.; Hussaini, I.M.; Webb, D.J.; Glass, W.F.; Allietta, M.; Gonias, S.L., 1995: Alpha 2-macroglobulin functions as a cytokine carrier to induce nitric oxide synthesis and cause nitric oxide-dependent cytotoxicity in the RAW 264.7 macrophage cell line. Nitric oxide (NO) is an important mediator of macrophage activities. We studied the regulation of macrophage NO synthesis by alpha 2-macroglobulin (alpha 2M), a proteinase inhibitor and carrier of certain growth factors, including transforming gro...

Anonymous, 1975: Eighteenth session, Rome, 8-27 November 1975. Reconstitution of the Intergovernmental Committee of the World Food Programme as a Committee on Food Aid Policies and Programmes. FAO conference: 75, C 75 42

Wikstrom P.; Larsson P O., 1987: Affinity fiber a new support for rapid enzyme purification by high performance liquid affinity chromatography. A new type of support for chromatographic use has been developed. Nonporous quartz fibre, with a mean diameter of 0.5 .mu.m, was silylated with mercaptopropyltrimethoxysilane. Tresyl chloride-activated dextran was covalently coupled to the SH grou...

Petrasko, M.S.; Berger, L.; Nahhas, H.; Sharma, S.C., 1998: Acute administration of captopril does not exchange basal, posthyperemic or posthandgrip forearm blood flow in patients with advanced congestive heart failure. Journal of Investigative Medicine 46(3): 196A, March

Miyata, R.; Kubo, T.; Nabeshima, E.; Kohyama, T.S., 2012: Common allometric response of open-grown leader shoots to tree height in co-occurring deciduous broadleaved trees. Annals of Botany 108(7): 1279-1286