geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in diabetic subjects with coronary artery disease


, : Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in diabetic subjects with coronary artery disease. Diabetes/Metabolism Research and Reviews 23(5): 368-371

Background Advanced glycation end products (AGEs)-receptor (RAGE) axis is implicated in diabetic vascular complication. Since a soluble form of RAGE (sRAGE) could be generated from the cleavage of cell surface RAGE in endothelial cells (ECs), serum sRAGE levels may be elevated in diabetes consequent to EC damage. In this study, we examined whether sRAGE levels were elevated in type 2 diabetic patients compared with non-diabetic healthy subjects.Methods Serum sRAGE levels were examined in 75 Japanese type 2 diabetic patients (29 men and 46 women; mean age 66 11 years) and 75 age-and sex-matched non-diabetic healthy control subjects. We explored the association between sRAGE levels and coronary artery disease (CAD) in diabetic patients.Results Serum sRAGE levels were significantly higher in diabetic patients than in non-diabetic subjects (965.3 +/- 544.2 vs 415 +/- 150.4 pg/mL, p < 0.001). In the univariate analysis, diastolic blood pressure (inversely), LDL cholesterol, triglycerides, HDL cholesterol, hemoglobin A(1c), and creatinine were significantly associated with sRAGE. After performing multivariate analyses, the presence of diabetes (p < 0.0001) was a sole independent determinant of sRAGE. Furthermore, there was a significant difference in sRAGE levels between diabetic patients with CAD and those without CAD (1680.6 +/- 891.1 vs 855.2 +/- 372.1 pg/mL, p < 0.001). Multiple stepwise regression analysis revealed that sRAGE and creatinine levels were independent determinants of CAD.Conclusions The present study demonstrated that serum sRAGE levels were significantly higher in type 2 diabetic patients than in non-diabetic subjects and positively associated with the presence of CAD. Copyright (c) 2006 John Wiley & Sons, Ltd.

US$19.90

PMID: 17024691

DOI: 10.1002/dmrr.690


Other references

Sutherland, C.E.; Dvoretzky, T.; Solomos, N.J., 2016: Wedgie-associated radiculitis in a quinquagenarian. NlmCategory="UNASSIGNED">Wedgies-the upward yanking of another's underpants from the rear to wedge them between the buttocks-can be administered playfully, maliciously, or adventurously; at forces ranging from gentle to "ato...

Fuzeau Braesch S., 1968: Research on xanthomattin in 2 insects locusta migratoria and oedipoda coerulescens. Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences Serie D Sciences Naturelles 267(23): 2030-2033

Gaiger A.; Quehenberger P.; Kahls P.; Funovics M.; Forstinger C.; Schick S.; Laczika K.; Lechner K.; Mannhalter C., 1992: Molecular genetic analysis in patients following bone marrow transplantation. European Journal of Clinical Investigation 22(4 PART 2): A23

Zheng, Z.S.; Chen, R.Z.; Xue, G.Z.; Grunberger, D.; Prystowsky, J.H., 1994: Caffeic acid phenethyl ester blocks EGF induction of ornithine decarboxylase gene expression. Journal of Investigative Dermatology 102(4): 641

Verso, M.; Iorio, A., 2008: Review: Perioperative LMW heparin does not reduce mortality after surgery more than unfractionated heparin in patients with cancer. Acp Journal Club 149(6): 11-11

Benthe, H.F.; Schmoldt, A., 1973: Persistence of poly chlorinated bi phenyls in rats. Archives of Toxicology 30(3): 207-214

SMITH.M.I.; McCLOSKY.W.T., 1947: The chemotherapeutic action of streptomycin and sulfone derivatives in experimental tuberculosis. Federation Proceedings 6(1): 373-373

Schiemann, U.; Born, C.; Brenner-Maucher, U.; Folwaczny, C., 2003: Chronic diarrhea after a journey to Sri Lanka. A 51-year-old woman was referred for evaluation of chronic diarrhea. She had spent a 14 day vacation in Sri Lanka three years ago. The clinical examination of the patient was unremarkable. Values for protein, iron, zinc, copper and folic acid were...

Larina, I.A.; Volkova, Z.M.; Zelevinskaia, S.A., 1958: The effect of antibiotics in the treatment of experimental gas gangrene. In vitro experiments have shown that the causative organisms of gas gangrene are sensitive to chlortetracy-cline but not to grisein. Chlortetracycline limited the gangrenous process, saving the lives of a considerable number of animals, provided t...

León Molinari, P.; Jiménez Monteagudo, M.; Barona Zamora, P.; Riol Diego, M.; Castro Paz, L.; Sierrasesúmaga Ariznavarreta, L., 1998: Recombinant human erythropoietin in anemia associated with pediatric cancer: study of the identification of predictors of response. Anales Espanoles de Pediatria 49(1): 17-22