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Esophageal pleomorphic giant cell carcinoma combined with small cell carcinoma


, : Esophageal pleomorphic giant cell carcinoma combined with small cell carcinoma. Pathology International 57(8): 523-528

Herein is presented the case of an esophageal pleomorphic giant cell carcinoma combined with small cell carcinoma (SCC). The patient, a 77-year-old man, initially presented with dysphagia and hoarseness, and endoscopy indicated a large esophageal tumor. Despite chemoradiation therapy, the patient died from widespread local extension of the tumor and distant metastases approximately 8 months after onset of the symptoms. Histologically, the primary tumor was composed of pleomorphic tumor components, SCC components, and a tiny focus of squamous cell carcinoma. The pleomorphic tumor cells, consisting of solid sheets of poorly cohesive epithelioid cells and numerous multinucleated giant cells with abundant eosinophilic cytoplasm, were immunohistochemically positive for vimentin and desmin, with scattered positivity for epithelial membrane antigen (EMA) and neuron-specific enolase (NSE), but negative for myoglobin. These findings were histopathologically compatible with pleomorphic giant cell carcinoma occurring at other sites such as the lung. SCC cells, morphologically similar to their pulmonary counterpart, were positive for EMA and some neuroendocrine markers such as chromogranin A and NSE, and occasionally positive for vimentin and desmin. Esophageal pleomorphic giant cell carcinoma can occur in close association with SCC, and should be included in the differential diagnosis of esophageal tumors showing pleomorphism.

US$19.90

PMID: 17610478

DOI: 10.1111/j.1440-1827.2007.02135.x


Other references

Smith, R.J.; Block, M.R.; Arieff, A.I.; Blumenkrantz, M.J.; Coburn, J.W., 1974: Hypernatremic, hyperosmolar coma complicating chronic peritoneal dialysis. Proceedings of the Clinical Dialysis and Transplant Forum: 96-99

Fernando, N.V.; Vanerkel, G.A.; Movat, H.Z., 1964: The Fine Structure Of Connective Tissues. Iv. The Intercellular Elements. The fine structure of the extracellular elements of connective tissue is described. Ground substance, which because of its high concentration of acid muco-polysaccharide, stains intensely with certain stains, can be visualized in the electron micr...

D.C.ommo S.; Mazzanti C.; Gori G.; Guerresi E., 1988: Modifications through the years of the indications for cesarean section. The results of a statistical analysis about 1526 Cesarean sections performed from October 1968 to December 1984 at the Obstetrical Department of Bologna University. A comparison has been made between an equal number of consecutive cesarean section...

Ríos Zambudio, A.; Sánchez Bueno, F.; García Marcilla, J.A.; Robles Campos, R.; Tamayo Rodríguez, M.E.; Balsalobre Salmerón, M.D.; Parrilla Paricio, P., 2001: Prognostic factors in gallbladder cancer. Carcinoma of the gallbladder is the most frequent biliary tract lesion but the 5-year survival is less than 5%. The aim of this study was to analyze the influence of several clinico-pathological variables on survival in a series of 226 carcinomas...

Steven, F.S., 1966: Evidence for a deficiency in inter-molecular cross-linking in collagen fibrils isolated from rheumatoid joints. Mature collagen fibrils are formed from tropocollagen monomers by lateral and longitudinal polymerisation through 2 or more distinct types of chemical cross-linkages. One type of cross-linkage is destroyed by cold alkali treatment. Collagen fibril...

Epstein, R.A., 1994: The legal regulation of genetic discrimination: old responses to new technology. Boston University Law Review. Boston University. School of Law 74(1): 1-23

dos Santos-Pinto, R.; Okamoto, T.; de Castro, A.L., 1970: Pharmacological effect of nandrolone phenylpropionate on the healing of dental extraction wounds: a histological investigation in rats. Journal of Nihon University School of Dentistry 12(2): 57-61

Sugrue, D.D.; Holmes, D.R.; Gersh, B.J.; Wood, D.L.; Osborn, M.J.; Hammill, S.C., 1987: Impact of intracardiac electrophysiologic testing on the management of elderly patients with recurrent syncope or near syncope. Seventy-five patients, 75 years of age and over, experienced recurrent syncope, with the etiology remaining unclear but presumably cardiogenic, after cardiac and neurologic examinations and noninvasive laboratory testing (including an electrocardi...

Bryant, R.G., 1996: Validated linear mixture modelling of Landsat TM data for mapping evaporite minerals on a playa surface; methods and applications. International Journal of Remote Sensing 17(2): 315-330

Jacobs A.E.M.; Benders A.A.G.M.; Oosterhof A.; Veerkamp J.H.; Wevers R.A.; Joosten E.G.M., 1991: Effect of various agents on the cytoplasmic calcium concentration in cultured human muscle cells. 1. We determined the cytoplasmic Ca2+ concentrations ([Ca2+]i) in cultured human muscle cells using the fluorescent indicator Quin-2. 2. The [Ca2+]i was dependent on the external Ca2+ concentration. Acetylcholine in the presence of external Ca2+ c...