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First round of a focused library of cholera toxin inhibitors

, : First round of a focused library of cholera toxin inhibitors. Carbohydrate Research 342(12-13): 1651-1660

C-Galactosides have been used as scaffolds to design a library of non-hydrolysable inhibitors of cholera toxin (CT). Test elements from the library were synthesized and found to inhibit CT binding to an asialofetuin-coated SPR chip with micromolar affinity. Preliminary results are reported.


PMID: 17597594

DOI: 10.1016/j.carres.2007.06.006

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