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First total synthesis of antitumor natural product (+)- and (-)-pericosine A: determination of absolute stereo structure


, : First total synthesis of antitumor natural product (+)- and (-)-pericosine A: determination of absolute stereo structure. Journal of Organic Chemistry 72(16): 6127-6134

The first total synthesis of (+)- and (-)-pericosine A has been achieved, enabling the revision and determination of the absolute configuration of this antitumor natural product as methyl (3S,4S,5S,6S)-6-chloro-3,4,5-trihydroxy-1-cyclohexene-1-carboxylate. Every step of this total synthesis proceeded well with excellent stereoselectivity. Structures of the intermediates in crucial steps were confirmed by detailed 2D NMR analysis.

US$19.90

PMID: 17628106

DOI: 10.1021/jo070715l


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Sigua-Rodriguez, Éder.A.; Goulart, D.Rangel.; Manzano, A.Celso.de.Moraes.; Asprino, L., 2017: A Rare Case of Malignant Fibrous Histiocytoma (Undifferentiated High-Grade Pleomorphic Sarcoma) of Malar Region. Malignant fibrous histiocytoma is a sarcoma with rare occurrence in the oral and maxillofacial region; surgery is the most reliable treatment. Inadequate resection of the sarcoma on the oral and maxillofacial region is associated with a high incid...

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