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Influence of estradiol on the benzo(a)pyrene hydroxylase activity induced by hexachlorocyclohexane

, : Influence of estradiol on the benzo(a)pyrene hydroxylase activity induced by hexachlorocyclohexane. Toxicology Letters 19(3): 279-285

Basal BP-hydroxylase activity was measured in male Swiss mice from the age of 3 weeks to 20 months. Maximal enzyme activity was at the age of 5 months. Comparison of the inducibility of BP-hydroxylase by HCH was also investigated in male and female mice of different ages. Male mice showed higher induction of BP-hydroxylase by HCH than females of the same ages. Sterilization of female mice enhanced enzyme induction. Estradiol exhibited competitive inhibition of BP-hydroxylase activity. After treatment with HCH for 8 months, female mice had a lower tumour incidence than males, and this paralleled a lower induction of BP-hydroxylase.


PMID: 6197771

DOI: 10.1016/0378-4274(83)90131-5

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