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Insulin secretion and insulin sensitivity in relation to fasting glucose in healthy subjects


, : Insulin secretion and insulin sensitivity in relation to fasting glucose in healthy subjects. Diabetes Care 30(3): 644-648

OBJECTIVE:--This study evaluated insulin secretion and insulin sensitivity in healthy subjects with normal fasting glucose. RESEARCH DESIGN AND METHODS--A total of 148 healthy women (aged 53-70 years) underwent a glucose-dependent arginine stimulation test and a 2-h euglycemic-hyperinsulinemic clamp. In the arginine test, arginine (5 g) was injected intravenously under baseline (fasting) conditions and after raising the glucose levels to 15 and >28 mmol/l. From this test, the acute insulin response (AIR) to arginine during the three glucose levels (AIR subscript 1(B, AIR subscript 2(B, and AIR subscript 3(B) were estimated. The subjects were divided into quartiles of fasting glucose (n = 37 in each group [range <4.32; 4.33-4.84; 4.85-5.22; and 5.23-6.1 mmol/l, respectively). RESULTS:--The results show that 1) AIR subscript 1(B was higher in subjects in the two highest quartiles (P = 0.004), 2) AIR subscript 3(B was higher in the quartile with the highest fasting glucose (P = 0.012), and 3) insulin sensitivity was reduced in subjects in the highest quartile (P = 0.026) compared with the lower quartiles. The results also show, in contrast, that AIR subscript 2(B did not show a similar trend to be increased at higher fasting glucose. CONCLUSIONS:--It is concluded that 1) raised fasting glucose (albeit still within normal values) augments baseline and maximal arginine-induced insulin secretion in healthy subjects, and 2) this is associated with reduced insulin sensitivity. This suggests that high, but still normal, fasting glucose may contribute to the augmented insulin secretion in subjects with low insulin sensitivity.

US$19.90

PMID: 17327334

DOI: 10.2337/dc06-1759


Other references

Peng, C.; Geneva, N.; Guo, Z.; Wang, L-Ping., 2017: Issues associated with Galilean invariance on a moving solid boundary in the lattice Boltzmann method. In lattice Boltzmann simulations involving moving solid boundaries, the momentum exchange between the solid and fluid phases was recently found to be not fully consistent with the principle of local Galilean invariance (GI) when the bounce-back sc...

Swift, P.G.F.; Walker, C., 1999: Normalisation of glycated haemoglobin in the first 12 months after diagnosis A marker of adequate insulin treatment. Hormone Research (Basel) 51(SUPPL 2): 92, Aug

Anderson D.C.; Schmalstieg F.S.; Springer T.A., 1986: Contributions of the mac 1 glycoprotein family to polymorphonuclear leukocyte adherence reactions. Pediatric Research 20(4 PART 2): 291A

Villanger, O.; Veel, T.; Raeder, M.G., 1993: Secretin causes H+ secretion from intrahepatic bile ductules by vacuolar-type H(+)-ATPase. Intrahepatic bile duct epithelial cells contribute to bile formation by hormone-dependently secreting HCO-3- to bile and H+ to periductular fluid. The present study was undertaken to determine whether the secretin-induced H+ secretion is due to ac...

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Dewey J.; Byerly P., 1979: The history of seismometry to 1900. Earthquake Information Bulletin 11(2): 64-70

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Underwood, W.; Ryan, A.; Somerville, S.C., 2017: An Arabidopsis Lipid Flippase Is Required for Timely Recruitment of Defenses to the Host-Pathogen Interface at the Plant Cell Surface. Deposition of cell wall-reinforcing papillae is an integral component of the plant immune response. The Arabidopsis PENETRATION 3 (PEN3) ATP binding cassette (ABC) transporter plays a role in defense against numerous pathogens and is recruited to...

Rao A.J.; Raj H.G.M.; Moudgal N.R., 1972: Effect of luteinizing hormone follicle stimulating hormone and their anti sera on gestation in the hamster mesocricetus auratus. Journal of Reproduction & Fertility 29(2): 239-249

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