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Linking SIRT2 to Parkinson's disease

, : Linking SIRT2 to Parkinson's disease. Acs Chemical Biology 2(8): 529-532

A recent study has identified selective inhibitors of the human silent information regulator 2 NAD(+)-dependent protein deacetylase, SIRT2, and has shown that these compounds protect against alpha-synuctein-mediated toxicity in cellular models of Parkinson's disease. The inhibitors were found to ameliorate dopaminergic cell death in vitro and in a Drosophila model of Parkinson's disease.


PMID: 17708669

DOI: 10.1021/cb700160d

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