geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway


, : Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway. Proceedings of the National Academy of Sciences of the United States of America 104(43): 17046-17051

Two major DNA repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), repair double-stranded DNA breaks (DSBs) in all eukaryotes. Additionally, several alternative end-joining pathways (or subpathways) have been reported that characteristically use short-sequence homologies at the DNA ends to facilitate joining. How a cell chooses which DNA repair pathway to use (at any particular DSB) is a central and largely unanswered question. For one type of DSB, there is apparently no choice. DSBs mediated by the lymphocyte-specific recombination activating gene (RAG) endonuclease are repaired virtually exclusively by NHEJ. Here we demonstrate that non-RAG-mediated DSBs can be similarly forced into the NHEJ pathway by physical association with the RAG endonuclease.

US$19.90

PMID: 17939999

DOI: 10.1073/pnas.0610928104


Other references

Wood, G.A., 1980: The cocoa pod borer - a menace to South East Asia. Acrocercops cramerellus (Sn.) is a very important pest of cacao in the Philippines and parts of Indonesia. It has recently been reported from Sabah. Information on its life-cycle and feeding habits is provided to warn growers in neighbouring regio...

Mishra, B.; Mandal, A.; Kumar, N., 1992: Mycotic prosthetic-valve endocarditis. Four fatal cases of mycotic endocarditis following open heart prosthetic surgery are reported from a Cardiothoracic Surgery Centre during a 1-yr period. All patients were male, aged 19-47 yrs. The mean duration from the date of heart valve replace...

Crook, T.M.; Rader, T.H.; Stewart, J.F., 2001: Effect of variety, population (stand) and nitrogen on sugarbeet quality in Michigan. The effect of N and stand density on the quality of sugarbeet cultivars US H20, Hilleshog E4 and Hilleshog E17 was investigated in a field experiment conducted in Michigan, USA, in 1998 and 1999. The treatments comprised 3 stand densities (130, 18...

Szarvas, T.; Jäger, T.; Laszlo, V.; Kramer, G.; Klingler, H.Christoph.; vom Dorp, F.; Romics, I.; Ergün, Süleyman.; Rübben, H., 2012: Circulating angiostatin, bFGF, and Tie2/TEK levels and their prognostic impact in bladder cancer. To assess the role and prognostic significance of angiostatin, basic fibroblast growth factor (bFGF), and tyrosine endothelial kinase (TEK/Tie2) in transitional cell bladder carcinoma. Angiostatin, bFGF, and TEK serum concentrations were measured...

Doré, S.; Kar, S.; Quirion, R., 1997: Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity. Insulin-like growth factors (IGF-I and IGF-II) are well known trophic factors and their specific receptors are uniquely distributed throughout the brain, being especially concentrated in the hippocampal formation. IGFs possess neurotrophic activit...

Ariel, N.; Avi-Dor, Y., 1975: Chloride-dependent restoration of coupling by oligomycin in rat liver mitochondria. In rat liver mitochondria suspended in KC1 medium, oligomycin interfered with the effect of uncouplers on energy conservation. It antagonized the effect of uncouplers that are weak acids (2,4-dinitrophenol etc.), but enhanced that of the lipid-pen...

Zak, B., 1954: A study of soil aeration and other factors in relation to the littleleaf disease of Pine. KEYWORDS: plant disorders \ Littleleaf disease \ Pinus echinata littleleaf disease \ protection \ forests \ soil air \ soil porosity

Messina A., 1989: The central polysyndactyly type iii of the hands clinical physiopathological and surgical considerations classification of lesions. Annales de Chirurgie de la Main 8(2): 135-145

Lustigman, S.; Makepeace, B.L.; Klei, T.R.; Babayan, S.A.; Hotez, P.; Abraham, D.; Bottazzi, M.Elena., 2017: Onchocerca volvulus: The Road from Basic Biology to a Vaccine. Human onchocerciasis - commonly known as river blindness - is one of the most devastating yet neglected tropical diseases, leaving many millions in sub-Saharan Africa blind and/or with chronic disabilities. Attempts to eliminate onchocerciasis, pr...

Jeong, S-Jin.; Kim, O-Soon.; Yoo, S-Rom.; Seo, C-Seob.; Kim, Y.; Shin, H-Kyoo., 2016: Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages. Gwakhyangjeonggi‑san (GHJGS) is a mixture of herbal plants, including Agastache rugosa, Perilla frutescens, Angelica dahurica, Areca catechu, Poria cocos, Magnolia officinalis, Atractylodes macrocephala, Citrus reticulata, Pinellia tern...