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Linking folding with aggregation in Alzheimers o-amyloid peptides

, : Linking folding with aggregation in Alzheimers o-amyloid peptides. Proceedings of the National Academy of Sciences of the United States of America23 104(43): 16880-16885

Growing evidence suggests that the o-amyloid (Ao) peptides of Alzheimer's disease are generated in early endosomes and that small oligomers are the principal toxic species. We sought to understand whether and how the solution pH, which is more acidic in endosomes than the extracellular environment, affects the conformational processes of Ao.


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