+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Microwave-assisted resolution of (R,S)-2-octanol by enzymatic transesterification

, : Microwave-assisted resolution of (R,S)-2-octanol by enzymatic transesterification. Journal of Molecular Catalysis B Enzymatic 48(1-2): 51-57

Novozym 435 (Candida antarctica lipase B innnobilized on polyacrylic resin) was used for the resolution of (R,S)-2-octanol with vinyl acetate as the acyl donor through transesterification. Comparison was studied to illustrate the advantage of microwave irradiation superior to the conventional heating on the enzymatic resolution reaction. It was found that the activity and enantioselectivity of Novozym 435 were enhanced dramatically under microwave irradiation. Increased thermal stability and reusability of Novozym 435 under microwave irradiation were also observed. Effects of reaction conditions, such as temperature, organic solvents, water activity, substrate ratio and enzyme load on the activity as well as enantioselectivity of Novozym 435 were also investigated. Under the optimum conditions, (S)-2-octanol was obtained at 50.5% conversion with 99% enantiomeric excess in 2 h under microwave irradiation.


DOI: 10.1016/j.molcatb.2007.06.009

Other references

Kalowski, S.; Radford, N.; Kincaid-Smith, P., 1974: Crystalline and macrocrystalline nitrofurantoin in the treatment of urinary-tract infection. New England Journal of Medicine 290(7): 385-387

Kennedy, D.J.; Allworth, B., 2001: Ovine Johne's disease--progress and challenges. Australian Veterinary Journal 79(7): 482-483

Buddana, S.Kumar.; Varanasi, Y.Venkata.Naga.; Shetty, P.Reddy., 2015: Fibrinolytic, anti-inflammatory and anti-microbial properties of α-(1-3)-glucans produced from Streptococcus mutans (MTCC 497). Streptococcus mutans (MTCC 497) cell associated α-(1-3)-glucans were isolated, characterized and evaluated for their bioactivity profile. Acid hydrolysis of α-(1-3)-glucans revealed presence of glucose moieties. Water insoluble α-(1-3)-glucans...

Niu, X.; Fan, Y.; Liu, X.; Li, X.; Li, P.; Wang, J.; Sha, Z.; Feng, Q., 2011: Repair of bone defect in femoral condyle using microencapsulated chitosan, nanohydroxyapatite/collagen and poly(L-lactide)-based microsphere-scaffold delivery system. Bone repair ability of microencapsulated chitosan, nanohydroxyapatite/collagen (nHAC), and poly(L-lactide) (PLLA)-based microsphere-scaffold delivery system was investigated in present research, with nHAC/PLLA composite scaffold as a control. Chit...

Urx, M.; Vondrackova, J.; Kovarik, L.; Horsky, O.; Herold, M., 1963: Paper chromatography of tetracyclines. Journal of Chromatography 11: 62-65

Ollier C.D., 1988: Deep weathering, groundwater and climate. Geografiska Annaler Series A: Physical Geography

Zhang, J-chun.; Chen, K-ji.; Zheng, G-juan., 2007: Regulatory effect of Chinese herbal compound for detoxifying and activating blood circulation on expression of NF-kappaB and MMP-9 in aorta of apolipoprotein E gene knocked-out mice. To observe the regulatory effect of Chinese herbal compound for detoxifying and activating blood circulation on expression of nuclear factor-kappaB (NF-kappaB) and matrix metalloproteinase-9 (MMP-9) in aorta of apolipoprotein E gene knocked-out (A...

Malkawi A.I.H.sein; Hassan W.F.; Sarma S.K., 2001: An efficient search method for finding the critical circular slip surface using the Monte Carlo technique. Locating the critical slip surface and the associated minimum factor of safety are two complementary parts in a slope stability analysis. A large number of computer programs exist to solve slope stability problems. Most of these programs, however,...

Anonymous, 2016: First IVF puppies 'open the door' for the conservation of endangered canids. Veterinary Record 177(24): 612-612

Formanek H.; Weidner H., 1981: 3 dimensional structure of the carbohydrate moiety of a lipo poly saccharide computer calculations. The cell wall of the mutant R595 of Salmonella minnesota contains a lipopolysaccharide in which a trisaccharide consisting of 3 KDO (2-keto-3-deoxyoctonate) residues is linked to a lipid termed lipid A. Considering the steric requirements of 14 ro...