+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Radical prostatectomy shortly after prostate biopsy does not affect operative difficulty or efficacy

, : Radical prostatectomy shortly after prostate biopsy does not affect operative difficulty or efficacy. Urology 69(6): 1128-1133

Objectives To examine whether radical prostatectomy (RP) conducted before 4 or 6 weeks after prostate biopsy is associated with surgical difficulty or efficacy. Many urologists recommend an interval of at least 4 to 6 weeks between prostate biopsy and RP.Methods Using our surgical database, we identified 2996 men undergoing open RP and compared the outcomes after surgery stratified by the interval from biopsy, analyzed as a dichotomous variable with cutpoints of either 4 or 6 weeks. The estimated blood loss and operating room time were considered surrogates for surgical difficulty, and surgical margin status and postoperative urinary and erectile function surrogates for surgical efficacy. We used regression models to assess whether the time to RP affected these surgical outcomes after controlling for the surgeon, surgeon experience, and various clinical and pathologic disease features.Results The interval between biopsy and RP was 4 weeks or less for 168 men (6%) and 6 weeks or less for 416 men (14%). Using an interval of 4 weeks or less or 6 weeks or less, multivariate mixed effects regression analyses did not show a significant association between early surgery and operating room time, estimated blood loss, surgical margin status, urinary continence, or erectile function (all P >= 0.18). Our results were sufficiently precise to exclude an important effect of early surgery.Conclusions The results of our study have shown that performing radical prostatectomy shortly after prostate biopsy, within 4 to 6 weeks, does not adversely influence surgical difficulty or efficacy.


PMID: 17572200

DOI: 10.1016/j.urology.2007.01.089

Other references

Dasgupta, P.K., 2007: Perchlorate: an enigma for the new millennium. Analytica Chimica Acta 567(1): 1-3

Newton, A.; Mackay, J.; Crossley, M., 2001: The N-terminal zinc finger of the erythroid transcription factor GATA-1 binds GATC motifs in DNA. The mammalian transcription factor GATA-1 is required for normal erythroid and megakaryocytic development. GATA-1 contains two zinc fingers, the C-terminal finger, which is known to bind (A/T)GATA(A/G) motifs in DNA and the N-finger, which is impo...

D.Lange Dzn, H., 1958: Research into the dynamic nature of the human fovea cortex systems with intermittent and modulated light II Phase shift in brightness and delay in color perception. josa/48/11/josa-48-11-784.pdf 48(11): 784-0

Ravn R.L., 1983: Paleobotanical relationships and stratigraphic importance of the carboniferous mio spore genus vestispora and questionably allied genera. Palynologists in Europe and North America regard species of the Carboniferous miospore genus Vestispora as useful biostratigraphic indicators. Recent paleobotanical studies, however, question the stratigraphic integrity of Vestispora, suggesting t...

Thomsen, P.; Rudenko, O.; Berezin, V.; Norrild, B., 1999: The HPV-16 E5 oncogene and bafilomycin A(1) influence cell motility. It is known that the proper function of the vacuolar H(+)-ATPase is inhibited by bafilomycin A(1). In transfected cells the E5 protein interacts with the 16 kDa subunit of the vacuolar H(+)-ATPase. Thereby the pH gradient in endocytic structures i...

Sharma, S.; Brown, G.C.; Cruess, A.F., 1998: Accuracy of visible retinal emboli for the detection of cardioembolic lesions requiring anticoagulation or cardiac surgery. Retinal Emboli of Cardiac Origin Study Group. To determine the accuracy of visible retinal emboli as a diagnostic "test" for the likelihood of receiving anticoagulation or cardiac surgery based on the results of transthoracic echocardiography, in the setting of acute retinal arteria...

Min; Kang; Hong; Jeong; Lee; Choi; Lee; Yang; Olson, 1993: Electronic and magnetic structures of the rare-earth permanent magnet Nd2Fe14B. Physical Review. B, Condensed Matter 48(9): 6217-6224

Shiryaeva, E.I.; Yarmolyuk, G.I., 1981: Cytoembryological study of genetically different forms of sugarbeet. The results are presented of a study of monogerm 2x, 3x and 4x forms, aneuploid forms with 26, 28, 29, 34, 35, 37 and 38 chromosomes, and forms with nuclear and cytoplasmic male sterility.

Trump, Fred., 1963: The Grange in Michigan. An agricultural history of Michigan over the past 90 years. The Michigan State Grange was founded in 1873, by representatives of 20 granges with a total of 50 members. Proceedings of the 88 annual sessions not only describe the activities of the grange, but reflect agricultural affairs and rural life of th...

Veatch, R.M., 2003: Inactivating a total artificial heart: special moral problems. It seems generally correct that patients (or their valid surrogates) should be able to withdraw consent for the use of the total artificial heart (TAH) just as they presently may withdraw consent for other life-prolonging technologies such as the...