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The gene balance hypothesis: from classical genetics to modern genomics


, : The gene balance hypothesis: from classical genetics to modern genomics. Plant Cell 19(2): 395-402

We evaluated the pharmacological characteristics of (R)-2-(2-aminothiazol-4-yl)-4'-{2-((2-hydroxy-2-phenylethyl)amino)-ethyl} acetanilide (YM178). YM178 increased cyclic AMP accumulation in Chinese hamster ovary (CHO) cells expressing human beta3-adrenoceptor (AR). The half-maximal effective concentration (EC50) value was 22.4 nM. EC50 values of YM178 for human beta1- and beta2-ARs were 10,000 nM or more, respectively.

US$19.90

PMID: 17293565

DOI: 10.1105/tpc.106.049338


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