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The role of cells refractory to productive infection in acute hepatitis B viral dynamics

, : The role of cells refractory to productive infection in acute hepatitis B viral dynamics. Proceedings of the National Academy of Sciences of the United States of America 104(12): 5050-5055

During acute hepatitis B virus (HBV) infection viral loads reach high levels ([almost equal to]10 superscript 10(B HBV DNA per ml), and nearly every hepatocyte becomes infected. Nonetheless, [almost equal to]85-95% of infected adults clear the infection. Although the immune response has been implicated in mediating clearance, the precise mechanisms remain to be elucidated. As infection clears, infected cells are replaced by uninfected ones. During much of this process the virus remains plentiful but nonetheless does not rekindle infection. Here, we analyze data from a set of individuals identified during acute HBV infection and develop mathematical models to test the role of immune responses in various stages of early HBV infection. Fitting the models to data we are able to separate the kinetics of the noncytolytic and the cytolytic immune responses, thus explaining the relative contribution of these two processes. We further show that we need to hypothesize that newly generated uninfected cells are refractory to productive infection. Without this assumption, viral resurgence is observed as uninfected cells are regenerated. Such protection, possibly mediated by cytokines, may also be important in resolving other acute viral infections.


PMID: 17360406

DOI: 10.1073/pnas.0603626104

Other references

Valdivia Alvarez, J.A.; Jiménez Misas, C.A.; Ferrá Salazar, C.; Mederos Cuervo, L.; Echemendía Font, M.; Mazón Zamora, D., 1988: The Laboratorio Nacional de Referencia de Mycobacteria y Tuberculosis in the antituberculosis campaign in Cuba. Revista Cubana de Medicina Tropical 40(2): 51-66

Burrell, A.B., 1938: Control of internal cork of apple with boron. Injection of boric acid and soil application of borax both reduced the amt. of internal cork by over 99% in the only orchard where symptoms were general in 1937. Limited studies in other blocks are corroborative. In non-treated checks there was in...

Bartolomejev, A.F.ser, Z., 1982: Containerization in agriculture and its influence on the handling of materials. II. Mechanizace zemedelstvi2(6): 241-243

Möller, G.; Möller, E., 1965: Plaque-formation by non-immune and x-irradiated lymphoid cells on monolayers of mouse embryo cells. Nature 208(5007): 260-263

Dabizzi, R.P.; Teodori, G.; Barletta, G.A.; Caprioli, G.; Baldrighi, G.; Baldrighi, V., 1990: Associated coronary and cardiac anomalies in the tetralogy of Fallot. An angiographic study. Numerous studies have pointed out the frequent association of tetralogy of Fallot (TF) with other cardiovascular defects and coronary tree anomalies. We found cardiac defects in 181 (68%) out of 265 patients with TF investigated by catheterization...

Waksman, I.; Bickel, A.; Szabo, A.; Weiss, M.; Eitan, A., 1999: Use of endoscopic trocar-cannula for chest drain insertion in trauma patients and others. Background: The insertion of a chest drain into the pleural space is a common procedure used for treatment in various intrathoracic abnormalities. Recently, a new technique for chest-tube insertion for pleural cavity drainage, using the disposable...

Osaki, M.; Sagara, K.; Tanaka, A., 1992: Effect of nitrogen application on growth of various organs of potato plant. In field experiments potatoes cv. Danshakuimo were planted at a rate of one tuber/hill and given 0, 150 or 300 kg N/ha. With increasing N fertilizer plant and tuber growth rates and N uptake and absorption increased. The N content of tubers stabil...

Singh, Y.; Swaroop, A.; Misra, V., 1979: Kidney lipids of weanling rats fed lysine threonine deficient rice diets. In weanling rats fed a rice diet deficient in lysine and threonine for three days, kidney total lipid was reduced. Total, free and esterified cholesterol were increased in the deficient group while triglyceride and free fatty acids were decreased....

Kim, J.D.; Hyun, Y.; Sohn, K.S.; Kim, T.J.; Woo, H.J.; Han, I.K., 2001: Optimal dietary ratio of spray dried plasma protein and dried porcine solubles in improving growth performance and immune status in pigs weaned at 21 days of age. An experiment was conducted to determine the optimal inclusion ratio of spray dried plasma protein (SDPP) and dried porcine solubles (DPS) for maximizing growth and improving immunity in weaned pigs. One hundred-fifty male (barrow) pigs were allot...

Navratil M.; Moravkova K.; Gafronova M.; Hruska F., 1987: Twenty year cohort study of the employees in an asbestos processing plant. In 1966, 520 employees and retired persons of an asbestos [A. Z.] processing plant were examined for the first time, their exposure having been at least five years at that time. This originated a cohort to be controlled by abreography annually wit...