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Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts

, : Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts. American Journal of Physiology. Gastrointestinal and Liver Physiology 287(2): G444-G451

VEGF is a highly specific stimulator of endothelial cells and may play an important role in angiogenesis in the process of tissue regeneration. We previously showed that cyclooxygenase-2 (COX-2) expressed in mesenchymal cells of the ulcer bed is involved in the ulcer repair process. To clarify the role of COX-2 in angiogenesis during gastric ulcer healing, we investigated the relation between COX-2 expression and VEGF production in human gastric fibroblasts in vivo and in vitro.


PMID: 15246970

DOI: 10.1152/ajpgi.00537.2003

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Ng, G.A.; Martin, W.; Rankin, A.C., 1999: Imaging of adenosine bolus transit following intravenous administration: insights into antiarrhythmic efficacy. Objective-To study the effects of the site of intravenous injection of adenosine and to assess the site of action of adenosine in the heart by correlating cardiac effects with bolus transit. Methods-Ten patients undergoing routine technetium (Tc-9...

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