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Comparative analysis of maternal-fetal interface in preeclampsia and preterm labor

, : Comparative analysis of maternal-fetal interface in preeclampsia and preterm labor. Cell and Tissue Research 329(3): 559-569

The maternal-fetal interface, a chimeric structure, is formed when fetal cytotrophoblasts (CTBs) from the placenta invade the uterine wall and its resident vasculature. In preeclampsia (PE), interstitial and endovascular invasion are often shallow, and fewer spiral arterioles are breached in toto. Our previous work has shown that faulty CTB differentiation to an invasive phenotype is a contributing factor. Here, we have tested the hypothesis that the constellation of morphological and molecular defects that are associated with PE are unique to this condition. Specifically, we have compared the histology of the maternal-fetal interface and CTB expression of stage-specific antigens in PE and in preterm labor (PTL) with or without inflammation. In the absence of inflammation, biopsies obtained after PTL were near normal at histological and molecular levels. In accord with previously published data, PE had severe negative effects on the endpoints analyzed. Biopsies obtained after PTL with inflammation had an intermediate phenotype. Our results suggest that the maternal-fetal interface from cases of PTL without inflammation can be used for comparative purposes, e.g., as age-matched controls, in studies of the effects of PE on cells in this region.


PMID: 17549520

DOI: 10.1007/s00441-007-0428-0

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Smith, G.D.; Sawyer, H.R.; Mirando, M.A.; Griswold, M.D.; Sadhu, A.; Reeves, J.J., 1996: Steady-state luteinizing hormone receptor messenger ribonucleic acid levels and endothelial cell composition in bovine normal- and short-lived corpora lutea. The short-lived corpus luteum (CL) contributes to reproductive inefficiency during the postpartum period in beef cows. The cause for the early demise of the short-lived CL is not fully understood but is believed to involve a premature release of p...

Folsom, TR.; Hodge, VF., 1975: Experiments suggesting some first steps in the dispersal and disposal of plutonium and other alpha emitters in the Ocean. Marine Sci Commun, 13-4: 213-247

Howell, B.W., 1932: Sarcoma of the Foot. Proceedings of the Royal Society of Medicine 25(4): 577-578

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Treugut, H.; Nyman, U.; Hildell, J.; Molde, A., 1981: Functional control of the renal transplant via sequential computerized tomography. First results. The enhancement of cortex medulla and arteria iliaca can be visualized separately, evaluated densitometrically and represented graphically by means of sequential computerized tomography of the renal transplant following intravenous contrast medium...

White, S.D.; Myers, S.J., 1997: Evidence of Astragalus lentiginosus var. borreganus growing from a heteromyid seed cache. Southwestern Naturalist. September; 423: 328-329

Sheps, S.G.; Kottke, B.A.; Tyce, G.M.; Flock, E.V., 1963: Effect of methyldopa on the metabolism of catecholamines and tryptophan in two cases of metastatic pheochromocytoma. CIRCULATION 28(4 Pt 2): 804

Li, J.; Wang, Y.; Jia, G.; Xu, Y.; Zhu, M.; Zhou, Y.; Zhang, Z., 2012: Comparison of leaf morphological characters among different major varieties of Rehmannia glutinosa. To provide theoretical evidences for the identification and selective breeding of different major varieties of Rehmannia glutinosa by comparing their leaf characters such as the shapes, non-glandular hairs and the size and density of stomata. The...

Nakajima, T.; Iwasawa, K.; Hazama, H.; Asano, M.; Okuda, Y.; Omata, M., 1997: Extracellular Mg-2+ inhibits receptor-mediated Ca-2+-permeable non-selective cation currents in aortic smooth muscle cells. The effects of extracellular Mg-2+ on receptor-mediated Ca-2+-permeable non-selective cation currents were investigated in a cultured aortic smooth muscle cell line (A7r5) from rat thoracic aorta, using the whole-cell voltage-clamp technique. Unde...

Swales, W.E., 1948: Enterohepatitis (blackhead) in turkeys; observations on transmission by the caecal worm (Heterakis gallinae). Canadian Journal of Comparative Medicine and Veterinary Science 12(4): 97-100