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Compensatory nicotine self-administration in rats during reduced access to nicotine: an animal model of smoking reduction


, : Compensatory nicotine self-administration in rats during reduced access to nicotine: an animal model of smoking reduction. Experimental and Clinical Psychopharmacology 16(1): 86-97

The ability of smoking reduction (e.g., decreasing cigarettes per day) to produce significant reductions in toxin exposure is limited by compensatory increases in smoking behavior. Characterizing factors contributing to the marked individual variability in compensation may be useful for understanding this phenomenon. The goal of the current study was to develop an animal model of smoking reduction and to begin to examine potential behavioral and pharmacokinetic contributors to compensation. Rats trained for nicotine self-administration (NSA) in unlimited access sessions were exposed to a progressive decrease in duration of access to nicotine from 23-hr/day to 10-, 6-, and 2-hr/day. Following a return to 23 hr/day access and extinction, single-dose nicotine pharmacokinetic parameters were determined. Rats exhibited a reduction in total daily nicotine intake during reduced access to NSA, but decreases in nicotine intake were not proportional to decreases in access duration. Compensatory increases in hourly infusion rate were also observed when access was decreased. The magnitude of compensation differed considerably among animals. Early session infusion rate during baseline was significantly correlated, while nicotine clearance was moderately correlated, with 1 measure of compensation. Infusion rates were transiently increased compared to prereduction levels when unlimited access was restored, and this effect was greatest in animals that had exhibited the greatest levels of compensation. These findings indicate that rats exhibit compensatory increases in NSA during reduced access to nicotine, with substantial individual variability. This model may be useful for characterizing underlying factors and potential consequences of compensatory smoking.

US$19.90

PMID: 18266555

DOI: 10.1037/1064-1297.16.1.86


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Osler, R.; Petrovic, N.; Ermacora, P.; Seljak, G.; Brzin, J.; Loi, N.; Cararro, L.; Ferrini, F.; Refatti, E., 2001: Control strategies of apple proliferation, a serious disease occurring both in Slovenia and in Italy. Apple proliferation (AP) is a serious disease that mainly affects apple trees. It is caused by a phytoplasma that diffused in Europe, particularly in the South. Recently, serious epidemics have been reported to occur in northern Italy, particularl...

Winter, G., 2007: Laughter therapy. Nursing Standard 1987) 21(14-16): 28-29

John, V.H.; Trezise, D.J.; Xie, X.M., 1998: Electrophysiological characterization of voltage-gated Na+ channels in the dorsal root ganglion cell line ND7-23. Journal of Physiology (Cambridge) 513P: 140P-141P, Dec

Mahjoub, M.R.; Trapp, M.L.; Quarmby, L.M., 2005: NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes. A key feature of the polycystic kidney diseases is aberrant cell proliferation, a consequence of dysfunctional ciliary signaling. The NIMA-related kinases (Nek) Nek1 and Nek8 carry the causal mutations of two of the eight established mouse models...

Hunt, K.M.; Ditton, R.B., 2002: Freshwater fishing participation patterns of racial and ethnic groups in Texas. The goal of this paper was to understand differences in the recreational fishing behaviour of African-American, Mexican-American, and Anglo anglers in Texas, USA. Hypotheses about different behaviours in recreational fishing were generated from do...

Sun, Z-Yue.; Asberom, T.; Bara, T.; Bennett, C.; Burnett, D.; Chu, I.; Clader, J.; Cohen-Williams, M.; Cole, D.; Czarniecki, M.; Durkin, J.; Gallo, G.; Greenlee, W.; Josien, H.; Huang, X.; Hyde, L.; Jones, N.; Kazakevich, I.; Li, H.; Liu, X.; Lee, J.; Maccoss, M.; Mandal, M.B.; McCracken, T.; Nomeir, A.; Mazzola, R.; Palani, A.; Parker, E.M.; Pissarnitski, D.A.; Qin, J.; Song, L.; Terracina, G.; Vicarel, M.; Voigt, J.; Xu, R.; Zhang, L.; Zhang, Q.; Zhao, Z.; Zhu, X.; Zhu, Z., 2012: Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo. Cyclic hydroxyamidines were designed and validated as isosteric replacements of the amide functionality. Compounds with these structural motifs were found to be metabolically stable and to possess highly desirable pharmacokinetic profiles. These d...

Bravo, Mónica.de.la.Peña.; Serpero, L.D.; Barceló, A.; Barbé, F.; Agustí, A.; Gozal, D., 2007: Inflammatory proteins in patients with obstructive sleep apnea with and without daytime sleepiness. Excessive daytime sleepiness (EDS) is one of the most frequent symptoms in patients with obstructive sleep apnea syndrome (OSAS). However, not all patients with OSAS manifest EDS. The aim of this study was to assess whether differential circulator...

Anonymous, 1973: Breeding pea varieties. The Dijon Technological Station for Plant Products in France carried out a study of certain physical and chemical characters in 60 smooth and wrinkled-seeded varieties for freezing. The occurrence of strange tastes was a result mainly of lipoxidas...

Gupta, P.; Singh, K.S.arda, D., 1981: Effect of different methods of drying on the quality of berseem hay. Indian journal of dairy science 34(1): 114-116

Tsang Chin Fu, 2000: Modeling groundwater flow and mass transport in heterogeneous media; issues and challenges. Proceedings of the