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Effect of tumor bulk on local control and survival of patients with T1 glottic cancer: a 30-year experience

, : Effect of tumor bulk on local control and survival of patients with T1 glottic cancer: a 30-year experience. International Journal of Radiation Oncology, Biology, Physics 69(5): 1389-1394

Purpose: To evaluate the effect of tumor bulk on local control and survival of patients with T1 glottic cancer.Methods and Materials: Effects of tumor bulk, T-stage, anterior-commissure involvement, treatment duration, and fraction size were analyzed in 208 patients; 136 had small tumors and 72 had bulky tumors. Anterior-commissure was involved in 54 patients. Treatment duration ranged from 39 to 64 days and fraction size ranged from 1.8 to 2.0 Gy. Median follow-up was 5.1 years.Results: Five-year actuarial local control rates were 86.1 % and 91.4% after radiotherapy and salvage laryngectomy. On univariate analysis, local control rates were 92.6% and 73.6% for small and bulky tumors (p = 0.03), 89.6% and 75.9% for patients without and with anterior-commissure involvement (p = 0.01), 92.6% and 75.6% when treatment duration was <= 50 days and > 50 days (p = 0.04), and 90.2% and 76.4% with 2 Gy and 1.8 Gy (p = 0.02) per fraction. On multivariate analysis, tumor bulk was the only significant factor that affected local control (p = 0.007). Ultimate local control rates after salvage were 97.1 % and 80.5 % for patients with small and bulky tumors. Disease-free survival rates at 5 years for small and bulky tumors were 96.3% and 84.7% (p = 0.001). Median duration to recurrence for small tumors was 30 months as compared with 11 months for bulky tumors.Conclusion: Tumor bulk is a highly significant prognostic factor for radiation control of T1 glottic cancer. Patients with bulky tumors had lower local control and disease-free survival rates and shorter duration to recurrence than those with small tumors.


PMID: 17869013

DOI: 10.1016/j.ijrobp.2007.05.077

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