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Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice

, : Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice. Journal of Clinical Investigation 118(3): 1027-1039

IL-7 is integral to the generation and maintenance of CD8(+) T cell memory, and insufficient IL-7 is believed to limit survival and the persistence of memory CD8(+) T cells. Here, we show that during the mouse T cell response to lymphocytic choriomeningitis virus, IL-7 enhanced the number of memory CD8(+) T cells when its administration was restricted to the contraction phase of the response. Likewise, IL-7 administration during the contraction phase of the mouse T cell response to vaccinia virus or a DNA vaccine potentiated antigen-specific CD8(+) memory T cell proliferation and function. Qualitatively, CD8(+) T cells from IL-7-treated mice exhibited superior recall responses and improved viral control. IL-7 treatment during the memory phase stimulated a marked increase in the number of memory CD8(+) T cells, but the effects were transient. IL-7 therapy during contraction of the secondary CD8(+) T cell response also expanded the pool of memory CD8(+) T cells. Collectively, our studies show differential effects of IL-7 on memory CD8(+) T cell homeostasis and underscore the importance of the timing of IL-7 therapy to effectively improve CD8(+) T cell memory and protective immunity. These findings may have implications in the clinical use of IL-7 as an immunotherapeutic agent to bolster vaccine-induced CD8(+) T cell memory.


PMID: 18246202

DOI: 10.1172/JCI32020

Other references

Driessen J.J.; Van Egmond J.; Van Der Pol F.; Crul J.F., 1987: Effects of two benzodiazepines and a benzodiazepine antagonist on neuromuscular blockade in the anesthetized cat. The interaction of diazepam and midazolam with nondepolarizing neuromuscular blocking drugs was studied in the sciatic nerve-tibialis anterior muscle preparation of the anaesthetized cat. Both diazepam and midazolam (0.3 mg/kg i.v.) caused a signi...

Hamilton Fairley D.; Koistinen R.; Seppala M.; Franks S., 1991: Steroid hormone regulation of sex hormone binding globulin shbg and insulin like growth factor binding protein 1 igfbp1 in hepatocarcinoma g2 cells. Journal of Endocrinology 131(SUPPL)

Gioidano, G., 1947: The specific gravity of wood at various moisture contents.. The author briefly reviews earlier work on the subject and then shows that the Forest Products Laboratory (Madison) formula (alphavf = 28rhoo) is not true for all European woods. In general he concludes that, although there is a straight-line rela...

Welsh, MJ.; Lyons, C.; Trudgett, A.; Rima, BK.; McCullough, SJ.; Orvell, C., 1992: Characteristics of a cetacean morbillivirus isolated from a porpoise (Phocoena phocoena). A virus isolated from a porpoise during the 1988 seal epizootic was shown to be a morbillivirus. In order to determine the relationship of the virus to phocine distemper virus (PDV) a battery of monoclonal antibodies raised against canine distempe...

Behunek, J.; Fukal, R.; Vagunda, S., 1956: Case of giant neurinoma. Ceskoslovenska Neurologie 19(4): 268-270

Joslin, E.P., 1959: A workman that needeth not to be ashamed [Elliott P. JOSLIN. New England Journal of Medicine 261: 455-459

Nussinovitch, A.; Velez-Silvestre, R.; Peleg, M., 1992: Mechanical properties of hydrocolloid gels filled with internally produced CO2 gas bubbles. Agar (2%), alginate (1% algin), and kappa-carrageenan (1.5%) gel specimens were prepared from mother solutions that contained 0-2.5% sodium bicarbonate (agar and carrageenan) or calcium carbonate (alginate). Upon immersion in a citric acid bath (0...

Scholz T.; Zajicek V.S.J., 1990: Life history of the tapeworm khawia sinensis hsu 1935 a carp parasite in the pond drazsky skalicany near blatna czechoslovakia. The life cycle of the tapeworm Khawia sinensis was studied on the basis of examination of 280 stock carp (Cyprinus carpio K 1-2)) and 9 671 water oligochaetos of the families Tubificidae and Naididae from the pond Drazsky Skalicany near Blatna fro...

Raynaud, F.; Evain-Brion, D., 1991: Protein kinase C activity in normal and psoriatic cells: cultures of fibroblasts and lymphocytes. Protein kinase C (PKC) activity was measured in cultures of fibroblasts from biopsies of the involved and uninvolved skin of seven patients with psoriasis and from the skin biopsies of nine normal controls. PKC activity was significantly increased...

Umaña-Taylor, A.J.; O'Donnell, M.; Knight, G.P.; Roosa, M.W.; Berkel, C.; Nair, R., 2014: Mexican-origin Early Adolescents' Ethnic Socialization, Ethnic Identity, and Psychosocial Functioning. The current study examined how parental ethnic socialization informed adolescents' ethnic identity development and, in turn, youths' psychosocial functioning (i.e., mental health, social competence, academic efficacy, externalizing behav...