+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Humoral immunity targeting site I of antigenic domain 2 of glycoprotein B upon immunization with different cytomegalovirus candidate vaccines

, : Humoral immunity targeting site I of antigenic domain 2 of glycoprotein B upon immunization with different cytomegalovirus candidate vaccines. Vaccine 26(1): 41-46

Glycoprotein B (gB) is a major component in several vaccines that are under development for prevention of disease by cytomegalovirus. It contains multiple determinants that are targets for neutralizing antibodies. One of them is site I of antigenic domain 2 (AD-2). The epitope, defined by short peptides, is quite conserved between different isolates. However, it is poorly immunogenic in natural infection. In this study we investigated the extent to which different vaccines, attenuated live Towne vaccine with or without priming with a canarypox virus coding for gB, or a recombinant gB vaccine adjuvanted with MF59, induced antibodies to this epitope. As in natural infection only a fraction of all. subjects developed antibody responses against site I of AD-2 following vaccination. We suggest that strategies that enhance immunogenicity of this epitope will improve vaccine efficacy.


PMID: 18063447

DOI: 10.1016/j.vaccine.2007.10.048

Other references

Orgeur, P.; Le-Dividich, J.; Colson, V.; Meunier-Salaun, M.C., 2002: La relation mere-jeune chez les porcins: De la naissance au sevrage. Modern production methods can induce negative consequences for pig welfare. In wild-pigs, as in domestic pigs reared in natural conditions, parturient females live in a matriarchal group and build a nest to protect their piglets. A selective bond...

Porzig, K.J.; Barbacid, M.; Aaronson, S.A., 1979: Biological properties and translational products of three independent isolates of feline sarcoma virus. Three transforming retroviruses have been isolated from naturally occurring tumors of outbred cats. In the present report, the biological properties of the SM, GA, and ST strains of feline sarcoma virus (FeSV) have been characterized in tissue cul...

Polhemus, John T., 1994: The identity and synonymy of the Belostomatidae (Heteroptera) of Johann Christian Fabricius 1775-1803. The six belostomatid names used by J. C. Fabricius are reviewed. Nepa grandis Linnaeus,1758 (= Lethocerus grandis), Nepa annulata Fabricius, 1781 (= Diplonychus annulatus) and Nides Fabricius, 1803 (= Appasus nepoides) are not controversial. Nepa...

Schirmbeck, R.; Zheng, X.; Roggendorf, M.; Geissler, M.; Chisari, F.V.; Reimann, J.; Lu, M., 2001: Targeting murine immune responses to selected T cell- or antibody-defined determinants of the hepatitis B surface antigen by plasmid DNA vaccines encoding chimeric antigen. By exchanging sequences from the middle-surface (MS) and small-surface (S) Ag of hepatitis B virus (HBV) with corresponding sequences of the MS Ag of woodchuck hepatitis virus, we constructed chimeric MS variants. Using these constructs as DNA vac...

Zhang, Y.; Xing, Y.; Zhang, L.; Mei, Y.; Yamamoto, K.; Mak, T.W.; You, H., 2012: Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1. To ensure genome stability, DNA must be replicated once and only once during each cell cycle. Cdt1 is tightly regulated to make sure that cells do not rereplicate their DNA. Multiple regulatory mechanisms operate to ensure degradation of Cdt1 in S...

Wysocka, B.; Denis, A.; Limon, J.; Izycka, E.; Roszkiewicz, A.; Drozyńska, E.; Jassem, J.; Imieliński, B.; Stoba, C., 1996: Klinefelter syndrome and neoplasia presentation of three new cases. Cancer Genetics and Cytogenetics 92(1): 85-86

Benoit, J.; Ayoub, A.; Rakic, P., 2015: Epigenetic stability in the adult mouse cortex under conditions of pharmacologically induced histone acetylation. NlmCategory="UNASSIGNED">Histone acetylation is considered a major epigenetic process that affects brain development and synaptic plasticity, as well as learning and memory. The transcriptional effectors and morphological changes resp...

Patriarche, G.; Glas, F.; Tchernycheva, M.; Sartel, C.; Largeau, L.; Harmand, J-Christophe.; Cirlin, G.E., 2008: Wurtzite to zinc blende phase transition in GaAs nanowires induced by epitaxial burying. We bury vertical free-standing core-shell GaAs/AlGaAs nanowires by a planar GaAs overgrowth. As the nanowires get buried, their crystalline structure progressively transforms: whereas the upper emerging part retains its initial wurtzite structure,...

Suzuki, H.; Miwa, C.; Ishihara, S., 2004: A Single Amino Acid Substitution Converts g-Glutamyltranspeptidase to a Class IV Cephalosporin Acylase (Glutaryl-7-Aminocephalosporanic Acid Acylase). Applied and Environmental Microbiology 70(10): 24-8

Anonymous, 1934: Sterilization Of Defectives: Departmental Committee's Report. British Medical Journal 1(3812): 161-165