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Hypolipidemic effect of flavonoids and cholestyramine in rats


, : Hypolipidemic effect of flavonoids and cholestyramine in rats. Latin American Journal of Pharmacy 26(3): 407-410

The present work evaluates the action of quercetin, rutin, morin and naringenin isolated or/and in association with cholestyramine on blood lipids of rats. These compounds were mixed to the diet (mark purina) containing 1 % of cholesterol and 0.1 % of cholic acid and they were administered in the dose of 30 mg for the flavonoids and 10 mg for cholestyramine. After thirty days, cholesterol, cholesterol-HDL and triacylglycerols were measured after retreat of blood. Results evidence that cholestyramine in association with quercetin present the largest percentual reduction of cholesterol. On the other hand, for cholesterol-HDL the level increase in the association of cholestyramine and naringenin showed a synergic effect, while the results for triacilglicerols indicated a reduction in all treatments being the best results obtained with association of cholestyramine and flavonoids.

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