+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy

, : Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiology of Disease 29(1): 142-160

We investigated the activation of the IL-1 beta system and markers of adaptive immunity in rat brain during epileptogenesis using models of temporal lobe epilepsy (TLE). The same inflammatory markers were studied in rat chronic epileptic tissue and in human TLE with hippocampal sclerosis (HS). IL-1 beta was expressed by both activated microglia and astrocytes within 4 h from the onset of status epilepticus (SE) in forebrain areas recruited in epileptic activity; however, only astrocytes sustained inflammation during epileptogenesis. Activation of the IL-1 beta system during epileptogenesis was associated with neurodegeneration and blood-brain barrier breakdown. In rat and human chronic epileptic tissue, IL-1 beta and IL-1 receptor type 1 were broadly expressed by astrocytes, microglia and neurons. Granulocytes appeared transiently in rat brain during epileptogenesis while monocytes/macrophages were present in the hippocampus from 18 h after SE onset until chronic seizures develop, and they were found also in human TLE hippocampi. In rat and human epileptic tissue, only scarce B- and T-lymphocytes and NK cells were found mainly associated with microvessels. These data show that specific inflammatory pathways are chronically activated during epileptogenesis and they persist in chronic epileptic tissue, suggesting they may contribute to the etiopathogenesis of TLE.


PMID: 17931873

DOI: 10.1016/j.nbd.2007.08.012

Other references

Odano, I.; Ohkubo, M.; Noguchi, E.; Ohtaki, H.; Shibaki, M.; Dobashi, S., 1998: Quantification of regional cerebral blood flow at the control state and loaded with diamox using split-dose 99mTc-ECD SPECT and venous blood samples. The purpose of the study is to develop a simple and less invasive method for quantifying regional cerebral blood flow (rCBF) at pre- and post Diamox test using split-dose 99mTc-ECD and SPECT. By employing a microsphere model, integral of input fun...

Anonymous, 1981: Draft environmental profile on Syria. Despite a steadily rising standard of living, Syria faces increasingly ominous problems in regard to its water, soil, and forest resources. Water pollution is Syria's most important water-related problem. Little progress has been made in elim...

Hudson, N., 1997: Excess long-term mortality in patients with ulcer complications. The cDNA encoding mac25 (IGFBP-7) was firsr derived from mRNA isolated from leptomeningial and senescent human mammary epithelial cells (1,2). The open reading frame was shown to predict a protein with homology to the amino terminus of the IGF bin...

Echternkamp, S.E.; Gregory, K.E., 2003: Reproductive efficiency in cattle selected for ovulation and twinning rate. Journal of Dairy Science 86(Supplement 1): 183

Depper, J.M.; Zvaifler, N.J.; Bluestein, H.G., 1982: Oropharyngeal Epstein-Barr virus excretion in rheumatoid arthritis. We hypothesized that the defective cellular regulation of Epstein-Barr virus (EBV) in rheumatoid arthritis (RA) might be reflected in an increased rate of oropharyngeal virus excretion, but we found that the prevalence of excretion in 45 RA patien...

Haddad, B.R.; Baldini, A.; Hughes, M.R., 1994: Comparative genomic hybridization with single cells after whole genome amplification. American Journal of Human Genetics 55(3 SUPPL ): A45

Heinemann, S., 1969: The Night of the Long Knives. Southwestern Medicine 50(5): 80-81

Profous-Juchelka, H.R.; Reuben, R.C.; Marks, P.A.; Rifkind, R.A., 1983: Transcriptional and post-transcriptional regulation of globin gene accumulation in murine erythroleukemia cells. The mechanism responsible for the accumulation of newly synthesized alpha- and beta-globin mRNA in the cytoplasm of induced murine erythroleukemia cells was examined by nuclear mRNA nascent chain elongation (run-off transcription). Hexamethylenebi...

Banaszak, H., 1997: Effects of some herbicides on hatch of Heterodera schachtii Schm. larvae. Studies were conducted in the spring of 1994 and 1995 in greenhouses at 16-25 degrees C to determine the influence of eight herbicides on the hatch of larvae of Heterodera schachtii. Herbicides were used at the recommended rates and effects were d...

Moynihan, M.H., 1969: Smithsonian Tropical Research Institute. Smithson. Year, 219-233