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LEF-1 activates the transcription of E2F1


, : LEF-1 activates the transcription of E2F1. Biochemical and Biophysical Research Communications 365(1): 149-153

LEF-1 and E2F are both transcription factors involved in cell proliferation, differentiation and apoptosis. The present study shows for the first time that LEF-1 associates with E2F1 and further beta-catenin independently activates the E2F-responsive reporter gene by attenuating the interaction between E2F1 and Histone deacetylase 1 (HDAC1), which indicates that LEF-1, except for its function in Wnt signaling, may play a distinct role via activating the transcription of E2F1.

US$19.90

PMID: 17980157

DOI: 10.1016/j.bbrc.2007.10.138


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