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Liranaftate cream in treatment of tinea cruris and tinea corporis: a multicenter randomized double-blind vehicle-controlled clinical trial

, : Liranaftate cream in treatment of tinea cruris and tinea corporis: a multicenter randomized double-blind vehicle-controlled clinical trial. Zhongguo Xinyao yu Linchuang Zazhi 26(12): 881-884

AIM: To study and evaluate the efficacy and safety of 2 % liranaftate cream in the topical treatment of tinea cruris and tinea corporis.METHODS: Clinical study was done on 144 patients with tinea cruris and tinea corporis for 4 weeks in a multiple-center randomized, double-blind, parallel trial. Patients were randomly divided into trial group (treated with 2 % liranaftate cream) and control group (treated with I % bifonazole cream); and creams were locally administered once daily in each group for 2 weeks. The clinical follow up was taken at 1 st, 2nd week since the beginning of treatment and 2 weeks after the treatment.RESULTS: One hundred and forty-two patients had completed the trials, with 70 in the control group and 72 in the trial group. The total cure rates were 68 % in trial group, and 61 % in control group. The total efficacy rate was 99 % in trial group, and 90 % in control group. The mycological cure rate was 99 % and 96 % in trial group and control group, respectively. No adverse effects occurred in both groups. There were no significant differences between the two groups Involving clinical efficacy, mycological effectiveness, integrative efficiency and adverse effects (P > 0.05).CONCLUSION: 2 % topical. liranaftate cream has the same good efficacy and safety profile as I % bifonazole cream in the treatment of tinea cruris and tinea corporis.


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