geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Metabolic alterations in medication-free patients with bipolar disorder: a 3T CSF-corrected magnetic resonance spectroscopic imaging study


, : Metabolic alterations in medication-free patients with bipolar disorder: a 3T CSF-corrected magnetic resonance spectroscopic imaging study. Psychiatry Research 162(2): 113-121

The objective of this study was to determine whether cerebrospinal fluid(CSF)-corrected concentrations of N-acetylaspartate are lower in several brain regions of drug- and medication-free subjects with bipolar disorder as compared with matched healthy controls. Bipolar subjects (n=21) and age- and sex-matched healthy control (n=21) were studied using proton magnetic resonance spectroscopic imaging on a 3T magnetic resonance (MR) scanner. Spectra were quantified using the LCModel, and metabolite values were CSF-corrected to yield metabolite concentrations. Fourteen regions of interest and five metabolite concentrations in each subject were selected for statistical analysis. We found that bipolar subjects had significantly decreased N-acetylaspartate concentrations in both caudate heads and the left lentiform nucleus. Choline and creatine in the head of the right caudate were also significantly decreased in bipolar subjects. Significantly increased myo-inositol was found in the left caudate head in bipolar subjects. Bipolar subjects showed significantly decreased glutamate/glutamine concentrations in the frontal white matter bilaterally and in the right lentiform nucleus. No differences were found for other metabolites examined. These preliminary findings suggest decreased neuronal density or viability in the basal ganglia and neurometabolic abnormalities in the frontal lobes of subjects with bipolar disorder.

US$19.90

PMID: 18164911

DOI: 10.1016/j.pscychresns.2007.08.004


Other references

Creswell M.W.; Chucholowski A.; Stanfield R.L.; Essenburg A.D.; Hamelehle K.L.; Krause B.R., 1991: Azapeptides a new series of semicarbazide acyl coenzyme a cholesterol acyltransferase acat inhibitors. Abstracts of Papers American Chemical Society 201(1-2): MEDI 118

Macrino, S.; Slater, H.; Aballay, A.; Goldfarb, I.William.; Caushaj, P.F., 2007: A three-decade review of thermal injuries among the elderly at a regional burn centre. To review trends in incidence and treatment of thermal injuries among the elderly. A 3-year retrospective review of medical records of people aged 65 years and older admitted to our burn centre over July 2003-June 2006. Elderly people with burns c...

Emoto, Yoshikadzu, 1929: Three new species of sulphur-oxidizing bacteria. Thiobacillus lobatus*(p. 148), T. crenatus*(p. 149), and T. umbonatus*(p. 150).

Kepczynski, J.; Kepczynska, E., 1997: Ethylene in seed dormancy and germination. The role of ethylene in the release of primary and secondary dormancy and the germination of non-dormant seeds under normal and stressed conditions is considered. In many species, exogenous ethylene, or ethephon - an ethylene-releasing compound st...

Tanaka Hiroyuki; Locat Jacques; Shibuya Satoru; Soon Tan Thiam; Shiwakoti Dinesh R., 2001: Characterization of Singapore, Bangkok, and Ariake clays. A soil investigation was carried out at two sites in Singapore and Bangkok, Southeast Asia, and the results were compared with those from a site in Ariake, Japan. Soil samples at all the sites were retrieved using the Japanese sampling method to n...

Lagarde, M., 1995: Fatty acids and health. This is an introduction to the symposium Fatty Acids and Health held at Marseille, France, 19-20 October, 1994.

Peter, B.; Polyansky, A.A.; Fanucchi, S.; Dirr, H.W., 2014: A Lys-Trp cation-π interaction mediates the dimerization and function of the chloride intracellular channel protein 1 transmembrane domain. Chloride intracellular channel protein 1 (CLIC1) is a dual-state protein that can exist either as a soluble monomer or in an integral membrane form. The oligomerization of the transmembrane domain (TMD) remains speculative despite it being implica...

Kaminski, M.A.; Kuhnt, W., 2004: What, if anything, is a Paratrochamminoides? A key to the morphology of the Cretaceous to Cenozoic species of Conglophragmium and Paratrochamminoides (Foraminifera). We present a review of the current taxonomical status of the genus Paratrochamminoides Soliman, 1972. We recognise five main subgroups of this genus based upon the following modes of coiling: trochospiral, streptospiral, glomospiral, triloculine o...

Yang, F.; Lazzarini, R.A., 1983: Analysis of the recombination event generating a vesicular stomatitis virus deletion defective interfering particle. c[complementary]DNA clones of different portions of the L cistron and 5'-terminal region of the vesicular stomatitis virus genome were prepared and used to identify the exact site of the deletion in the defective interfering particle, DI-LT....

Vrtovsnik, F.; Porcher, R.; Michel, C.; Hufnagel, G.; Queffeulou, G.; Mentre, F.; Mignon, F., 2000: Survival of elderly patients on peritoneal dialysis Retrospective and monocentric study of 292 patients from 1982 to 1999. Journal of the American Society of Nephrology 11(Program and Abstract Issue): 246A, September