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No evidence for association between tau gene haplotypic variants and susceptibility to Creutzfeldt-Jakob disease


, : No evidence for association between tau gene haplotypic variants and susceptibility to Creutzfeldt-Jakob disease. Bmc Medical Genetics 8: 77-77

Background: A polymorphism at codon 129 of the prion protein gene ( PRNP) is the only well-known genetic risk factor for Creutzfeldt-Jakob disease (CJD). However, there is increasing evidence that other loci outside the PRNP open reading frame might play a role in CJD aetiology as well.Methods: We studied tau protein gene ( MAPT) haplotypic variations in a population of sporadic and variant CJD patients. We tested 6 MAPT haplotype tagging SNPs (htSNPs) in a Dutch population-based sample of sporadic CJD (sCJD) patients and a cognitively normal control group of similar age distribution. We genotyped the same polymorphisms in two other sample groups of sCJD cases from Italy and the UK. In addition, we compared MAPT haplotypes between sCJD and variant CJD (vCJD) patients.Results: Single locus and haplotype analyses did not detect any significant difference between sCJD cases and controls. When we compared MAPT haplotypes between sCJD and variant CJD ( vCJD) patients, we found that two of them were represented differently (H1f: 8% in sCJD versus 2% in vCJD; H1j: 1% in sCJD versus 7% in vCJD). However, these two haplotypes were rare in both groups of patients, and taking the small sample sizes into account, we cannot exclude that the differences are due to chance. None of the p-values remained statistically significant after applying a multiple testing correction.Conclusion: Our study shows no evidence for an association between MAPT gene variations and sCJD, and some weak evidence for an association to vCJD.

US$19.90

PMID: 18072964

DOI: 10.1186/1471-2350-8-77


Other references

Smith, E.A., 1908: Obituary Notice, S I Da Costa. Proceedings of the Malacological Society of London, 8 2

Odukoya, O.; Shklar, G., 1982: Two-phase carcinogenesis in hamster buccal pouch. A two-phase mechanism of chemical carcinogenesis in hamster buccal pouch has been demonstrated. Painting of buccal pouches three times weekly with a 0.1 percent solution of 7,12-dimethylbenz(a)anthracene (DMBA) in mineral oil for 10 weeks resulted...

Dağlar, Bülent.; Delialioğlu, O.M.; Minareci, E.; Taşbaş, Bülent.A.; Bayrakci, K.; Günel, Uğur., 2010: An alternative fixation method for the treatment of unstable distal clavicle fractures: locked distal radius plate. Optimal surgical fixation method for displaced distal clavicle fractures should not impose limitations on neighboring joint movements. We evaluated the results of surgical treatment of displaced distal clavicle fractures using locked distal radius...

Bohte, Sander, M., 2004: The evidence for neural information processing with precise spike-times: A survey. This paper surveys recent findings in neuroscience regarding the behavioral relevancy of the precise timing with which real spiking neurons emit spikes. The literature suggests that in almost any system where the processing-speed of a neural (sub)...

Petinou, K.; Theodorou, E., 2016: Early phonetic development in typically developing children: A longitudinal investigation from Cypriot-Greek child data. The current longitudinal study examined the acquisition of consonantal singleton segments in Cypriot-Greek. The study's aims were: (a) to determine the acquisition of segments for manner and place of articulation as a function of age and word...

Delaney, C., 1990: The hajj: sacred and secular. The paper considers why, against any rational calculus, thousands of Turks living in Europe each year undertake the arduous journey back to Turkey at vast expense, in physical discomfort and at risk of life. Based on material gathered in two Turki...

Guillery R.W., 1982: The optic chiasm of the vertebrate brain. Neff, Wd. . Contributions To Sensory Physiology, Vol. 7. Xiii 242p. Academic Press, Inc: New York, N.y., Usa; London, England. Illus. P39-74

Lavy, T.L.; Mattice, J.D.; Norris, L.A., 1984: Exposure of forest workers using herbicides measured. Knapsack spray operatives in forests appeared to be more exposed to herbicide sprays (2,4-D) than was the case where other forms of application were used. Comparison of margin of safety values (no observed effect divided by absorbed dose as determ...

A.Dadkhah, 2013: Allelopathic effect of sugar beet Beta vulgaris and eucalyptus Eucalyptus camaldulensis on seed germination and growth of Portulaca oleracea. Two experiments, a Petri dish assay and a pot experiment were carried out to evaluate possible allelopathic effects of water extracts (0, 10 and 20 g L<sup> 1</sup>) of sugar beet (<em>Beta vulgaris</em>) and eucalyptus (&l...

Stikov, N.; Keenan, K.E.; Pauly, J.M.; Smith, R.Lane.; Dougherty, R.F.; Gold, G.E., 2011: Cross-relaxation imaging of human articular cartilage. In this article, cross-relaxation imaging is applied to human ex vivo knee cartilage, and correlations of the cross-relaxation imaging parameters with macromolecular content in articular cartilage are reported. We show that, unlike the more common...